HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16361-y |
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doaj-31affdab15104a389accac5fde35981f2021-05-23T11:15:45ZengNature Publishing GroupNature Communications2041-17232020-05-0111111710.1038/s41467-020-16361-yHDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s diseasePing-Chieh Pao0Debasis Patnaik1L. Ashley Watson2Fan Gao3Ling Pan4Jun Wang5Chinnakkaruppan Adaikkan6Jay Penney7Hugh P. Cam8Wen-Chin Huang9Lorena Pantano10Audrey Lee11Alexi Nott12Trongha X. Phan13Elizabeta Gjoneska14Sara Elmsaouri15Stephen J. Haggarty16Li-Huei Tsai17Picower Institute for Learning and Memory, Massachusetts Institute of TechnologyChemical Neurobiology Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital and Harvard Medical SchoolPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyChemical Neurobiology Laboratory, Departments of Neurology and Psychiatry, Massachusetts General Hospital and Harvard Medical SchoolPicower Institute for Learning and Memory, Massachusetts Institute of TechnologyDefects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases.https://doi.org/10.1038/s41467-020-16361-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ping-Chieh Pao Debasis Patnaik L. Ashley Watson Fan Gao Ling Pan Jun Wang Chinnakkaruppan Adaikkan Jay Penney Hugh P. Cam Wen-Chin Huang Lorena Pantano Audrey Lee Alexi Nott Trongha X. Phan Elizabeta Gjoneska Sara Elmsaouri Stephen J. Haggarty Li-Huei Tsai |
| spellingShingle |
Ping-Chieh Pao Debasis Patnaik L. Ashley Watson Fan Gao Ling Pan Jun Wang Chinnakkaruppan Adaikkan Jay Penney Hugh P. Cam Wen-Chin Huang Lorena Pantano Audrey Lee Alexi Nott Trongha X. Phan Elizabeta Gjoneska Sara Elmsaouri Stephen J. Haggarty Li-Huei Tsai HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease Nature Communications |
| author_facet |
Ping-Chieh Pao Debasis Patnaik L. Ashley Watson Fan Gao Ling Pan Jun Wang Chinnakkaruppan Adaikkan Jay Penney Hugh P. Cam Wen-Chin Huang Lorena Pantano Audrey Lee Alexi Nott Trongha X. Phan Elizabeta Gjoneska Sara Elmsaouri Stephen J. Haggarty Li-Huei Tsai |
| author_sort |
Ping-Chieh Pao |
| title |
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease |
| title_short |
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease |
| title_full |
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease |
| title_fullStr |
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease |
| title_full_unstemmed |
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease |
| title_sort |
hdac1 modulates ogg1-initiated oxidative dna damage repair in the aging brain and alzheimer’s disease |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-05-01 |
| description |
Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases. |
| url |
https://doi.org/10.1038/s41467-020-16361-y |
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