Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

A common strategy to target nanoparticles to tumours is conjugation with specific antibodies, targeting protein expressed preferentially by cancer cells. Here the authors show that the number of antibodies bound to the nanoparticle influences the targeting abilityin vitro and in vivo.

Bibliographic Details
Main Authors: Miriam Colombo, Luisa Fiandra, Giulia Alessio, Serena Mazzucchelli, Manuela Nebuloni, Clara De Palma, Karsten Kantner, Beatriz Pelaz, Rany Rotem, Fabio Corsi, Wolfgang J. Parak, Davide Prosperi
Format: Article
Language:English
Published: Nature Publishing Group 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13818
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spelling doaj-31b037daafdb46eeb3c7cc68a126dbc72021-05-11T10:43:19ZengNature Publishing GroupNature Communications2041-17232016-12-017111410.1038/ncomms13818Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodiesMiriam Colombo0Luisa Fiandra1Giulia Alessio2Serena Mazzucchelli3Manuela Nebuloni4Clara De Palma5Karsten Kantner6Beatriz Pelaz7Rany Rotem8Fabio Corsi9Wolfgang J. Parak10Davide Prosperi11Dipartimento di Biotecnologie e Bioscienze, Università di Milano-BicoccaOspedale L. SaccoDipartimento di Biotecnologie e Bioscienze, Università di Milano-BicoccaOspedale L. SaccoOspedale L. SaccoOspedale L. SaccoFachbereich Physik, Philipps Universität MarburgFachbereich Physik, Philipps Universität MarburgDipartimento di Biotecnologie e Bioscienze, Università di Milano-BicoccaDipartimento di Scienze Biomediche e Cliniche ‘Luigi Sacco’, Università di MilanoFachbereich Physik, Philipps Universität MarburgDipartimento di Biotecnologie e Bioscienze, Università di Milano-BicoccaA common strategy to target nanoparticles to tumours is conjugation with specific antibodies, targeting protein expressed preferentially by cancer cells. Here the authors show that the number of antibodies bound to the nanoparticle influences the targeting abilityin vitro and in vivo.https://doi.org/10.1038/ncomms13818
collection DOAJ
language English
format Article
sources DOAJ
author Miriam Colombo
Luisa Fiandra
Giulia Alessio
Serena Mazzucchelli
Manuela Nebuloni
Clara De Palma
Karsten Kantner
Beatriz Pelaz
Rany Rotem
Fabio Corsi
Wolfgang J. Parak
Davide Prosperi
spellingShingle Miriam Colombo
Luisa Fiandra
Giulia Alessio
Serena Mazzucchelli
Manuela Nebuloni
Clara De Palma
Karsten Kantner
Beatriz Pelaz
Rany Rotem
Fabio Corsi
Wolfgang J. Parak
Davide Prosperi
Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
Nature Communications
author_facet Miriam Colombo
Luisa Fiandra
Giulia Alessio
Serena Mazzucchelli
Manuela Nebuloni
Clara De Palma
Karsten Kantner
Beatriz Pelaz
Rany Rotem
Fabio Corsi
Wolfgang J. Parak
Davide Prosperi
author_sort Miriam Colombo
title Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
title_short Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
title_full Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
title_fullStr Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
title_full_unstemmed Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
title_sort tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-12-01
description A common strategy to target nanoparticles to tumours is conjugation with specific antibodies, targeting protein expressed preferentially by cancer cells. Here the authors show that the number of antibodies bound to the nanoparticle influences the targeting abilityin vitro and in vivo.
url https://doi.org/10.1038/ncomms13818
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AT davideprosperi tumourhomingandtherapeuticeffectofcolloidalnanoparticlesdependonthenumberofattachedantibodies
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