Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation
The authors show that the pathogen Staphylococcus aureus induces a distinct airway immunometabolic response, dominated by release of itaconate. This metabolite, in turn, potentiates extracellular polysaccharide synthesis and biofilm formation in S. aureus, which may facilitate chronic infection.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21718-y |
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doaj-31b0833e7deb4acab5af4327ac64931d2021-03-11T11:30:56ZengNature Publishing GroupNature Communications2041-17232021-03-0112111310.1038/s41467-021-21718-yStaphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formationKira L. Tomlinson0Tania Wong Fok Lung1Felix Dach2Medini K. Annavajhala3Stanislaw J. Gabryszewski4Ryan A. Groves5Marija Drikic6Nancy J. Francoeur7Shwetha H. Sridhar8Melissa L. Smith9Sara Khanal10Clemente J. Britto11Robert Sebra12Ian Lewis13Anne-Catrin Uhlemann14Barbara C. Kahl15Alice S. Prince16Sebastián A. Riquelme17Department of Pediatrics, Columbia UniversityDepartment of Pediatrics, Columbia UniversityDepartment of Pediatrics, Columbia UniversityDepartment of Medicine, Columbia UniversityDepartment of Pediatrics, Columbia UniversityDepartment of Biological Sciences, University of CalgaryDepartment of Biological Sciences, University of CalgaryDepartment of Genetics and Genomic Sciences, Mt. Sinai Icahn School of MedicineDepartment of Genetics and Genomic Sciences, Mt. Sinai Icahn School of MedicineDepartment of Genetics and Genomic Sciences, Mt. Sinai Icahn School of MedicineSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of MedicineSection of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of MedicineDepartment of Genetics and Genomic Sciences, Mt. Sinai Icahn School of MedicineDepartment of Biological Sciences, University of CalgaryDepartment of Medicine, Columbia UniversityInstitute of Medical Microbiology Münster, University HospitalDepartment of Pediatrics, Columbia UniversityDepartment of Pediatrics, Columbia UniversityThe authors show that the pathogen Staphylococcus aureus induces a distinct airway immunometabolic response, dominated by release of itaconate. This metabolite, in turn, potentiates extracellular polysaccharide synthesis and biofilm formation in S. aureus, which may facilitate chronic infection.https://doi.org/10.1038/s41467-021-21718-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kira L. Tomlinson Tania Wong Fok Lung Felix Dach Medini K. Annavajhala Stanislaw J. Gabryszewski Ryan A. Groves Marija Drikic Nancy J. Francoeur Shwetha H. Sridhar Melissa L. Smith Sara Khanal Clemente J. Britto Robert Sebra Ian Lewis Anne-Catrin Uhlemann Barbara C. Kahl Alice S. Prince Sebastián A. Riquelme |
| spellingShingle |
Kira L. Tomlinson Tania Wong Fok Lung Felix Dach Medini K. Annavajhala Stanislaw J. Gabryszewski Ryan A. Groves Marija Drikic Nancy J. Francoeur Shwetha H. Sridhar Melissa L. Smith Sara Khanal Clemente J. Britto Robert Sebra Ian Lewis Anne-Catrin Uhlemann Barbara C. Kahl Alice S. Prince Sebastián A. Riquelme Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation Nature Communications |
| author_facet |
Kira L. Tomlinson Tania Wong Fok Lung Felix Dach Medini K. Annavajhala Stanislaw J. Gabryszewski Ryan A. Groves Marija Drikic Nancy J. Francoeur Shwetha H. Sridhar Melissa L. Smith Sara Khanal Clemente J. Britto Robert Sebra Ian Lewis Anne-Catrin Uhlemann Barbara C. Kahl Alice S. Prince Sebastián A. Riquelme |
| author_sort |
Kira L. Tomlinson |
| title |
Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation |
| title_short |
Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation |
| title_full |
Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation |
| title_fullStr |
Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation |
| title_full_unstemmed |
Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation |
| title_sort |
staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-03-01 |
| description |
The authors show that the pathogen Staphylococcus aureus induces a distinct airway immunometabolic response, dominated by release of itaconate. This metabolite, in turn, potentiates extracellular polysaccharide synthesis and biofilm formation in S. aureus, which may facilitate chronic infection. |
| url |
https://doi.org/10.1038/s41467-021-21718-y |
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