Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids

The biosynthesis of pyridine rings is still poorly understood. Here the authors propose a biosynthetic pathway for pyridine-containing rubrolones, which is characterized by a non-enzymatic condensation and cyclization of the pyridine moiety.

Bibliographic Details
Main Authors:	Yijun Yan, Jing Yang, Zhiyin Yu, Mingming Yu, Ya-Tuan Ma, Li Wang, Can Su, Jianying Luo, Geoffrey P. Horsman, Sheng-Xiong Huang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13083

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spelling	doaj-31b58558e98149e0865282c772e6c8b22021-05-11T11:20:24ZengNature Publishing GroupNature Communications2041-17232016-10-017111010.1038/ncomms13083Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloidsYijun Yan0Jing Yang1Zhiyin Yu2Mingming Yu3Ya-Tuan Ma4Li Wang5Can Su6Jianying Luo7Geoffrey P. Horsman8Sheng-Xiong Huang9State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesDepartment of Chemistry & Biochemistry, Wilfrid Laurier UniversityState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesThe biosynthesis of pyridine rings is still poorly understood. Here the authors propose a biosynthetic pathway for pyridine-containing rubrolones, which is characterized by a non-enzymatic condensation and cyclization of the pyridine moiety.https://doi.org/10.1038/ncomms13083
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yijun Yan Jing Yang Zhiyin Yu Mingming Yu Ya-Tuan Ma Li Wang Can Su Jianying Luo Geoffrey P. Horsman Sheng-Xiong Huang
spellingShingle	Yijun Yan Jing Yang Zhiyin Yu Mingming Yu Ya-Tuan Ma Li Wang Can Su Jianying Luo Geoffrey P. Horsman Sheng-Xiong Huang Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids Nature Communications
author_facet	Yijun Yan Jing Yang Zhiyin Yu Mingming Yu Ya-Tuan Ma Li Wang Can Su Jianying Luo Geoffrey P. Horsman Sheng-Xiong Huang
author_sort	Yijun Yan
title	Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids
title_short	Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids
title_full	Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids
title_fullStr	Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids
title_full_unstemmed	Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids
title_sort	non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-10-01
description	The biosynthesis of pyridine rings is still poorly understood. Here the authors propose a biosynthetic pathway for pyridine-containing rubrolones, which is characterized by a non-enzymatic condensation and cyclization of the pyridine moiety.
url	https://doi.org/10.1038/ncomms13083
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Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids

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