Human papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis

• Main Authors: Romina A Tejada, Kris G Vargas, Vicente Benites-Zapata, Edward Mezones-Holguín, Rafael Bolaños-Díaz, Adrian V Hernández
• Format: Article
• Language: English
• Published: Instituto Nacional de Salud Pública 2017-01-01
• Series: Salud Pública de México
• Subjects: Papillomavirus vaccines; Condyloma acuminata; papillomatosis; meta-analysis
• Online Access: http://www.saludpublica.mx/index.php/spm/article/view/7824

Objective. To review evidence on the efficacy of HPV vaccines in the prevention of non-cancer lesions (anogenital warts [AGW], recurrent laryngeal papillomatosis and oral papillomatosis). Materials and methods. We conducted a systematic review of randomized trials. We performed random effect models and effects were reported as relative risks (RR) and their confidence intervals (95%CI) following both intention to treat (ITT) and per protocol (PP) analyses. Results. We included six studies (n=27 078). One study was rated as high risk of bias. One study could not be included in the meta-analysis because it provided combined results. We found that quadrivalent vaccine reduced the risk of AGW by 62% (RR: 0.38, 95%CI:0.32-0.45, I2:0%) in the ITT analysis and by 95% (RR: 0.05, 95%CI:0.01-0.25, I2:66%) in the PP analysis. Subgroup analyses of studies in women or with low-risk of bias provided similar results. Conclusion. HPV quadrivalent vaccine is efficacious in preventing AGW in men and women.