Study of Acute Toxicity and Irritant Effect of Nasal Spray Naltrexone Hydrochloride
Introduction. Acute toxicity of naltrexone hydrochloride nasal spray during intragastric administration to mice and local irritant effect on rabbits was studied. At all stages of the experiment, observations were made on the General condition of the animals. The state of homeostasis was evaluated us...
Main Authors: | Yu. M. Domnina, V. V. Suslov, S. A. Kedik, D. A. Akhmedova, A. P. Malkova |
---|---|
Format: | Article |
Language: | Russian |
Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2021-05-01
|
Series: | Разработка и регистрация лекарственных средств |
Subjects: | |
Online Access: | https://www.pharmjournal.ru/jour/article/view/856 |
Similar Items
-
RATIONALE FOR THE SELECTION OF AUXILIARY COMPONENTS FOR THE NALTREXONE HYDROCHLORIDE NASAL SPRAY
by: Y. M. Domnina, et al.
Published: (2019-01-01) -
Microbiological Estimation of Nasal Spray Containing Naltrexone Hydrochloride
by: Yu. M. Domnina, et al.
Published: (2020-11-01) -
Quantitative Determination of Benzalconium Chloride in the Naltrexone Hydrochloride Nasal Spray
by: Yu. M. Domnina, et al.
Published: (2020-11-01) -
Quantitative Determination of Naltrexone Hydrochloride in a Nasal Spray by High-performance Liquid Chromatography
by: Yu. M. Domnina, et al.
Published: (2020-05-01) -
Approaches to the Development of a Low-dose Naltrexone Preparation in the Form of a Nasal Spray (Review)
by: Yu. M. Domnina, et al.
Published: (2021-02-01)