Nonocarbolines A–E, <i>β</i>-Carboline Antibiotics Produced by the Rare Actinobacterium <i>Nonomuraea</i> sp. from Indonesia

Nonocarbolines A–E, <i>β</i>-Carboline Antibiotics Produced by the Rare Actinobacterium <i>Nonomuraea</i> sp. from Indonesia

During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, <i>Nonomuraea</i> sp. 1808210CR was found to produce five unprecedented <i>&#946;</i>-carboline derivatives, nonocarbolines A&#8722;E (<b>1&...

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Main Authors: Gian Primahana, Chandra Risdian, Tjandrawati Mozef, Enge Sudarman, Matthias Köck, Joachim Wink, Marc Stadler
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Antibiotics
Subjects:
<i>nonomuraea</i> sp. 1808210 cr
rare actinobacteria
secondary metabolite
<i>β</i>-carbolines
Online Access:https://www.mdpi.com/2079-6382/9/3/126
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spelling doaj-31c42cfe7f984c0aa32b7bf0a297e3a12020-11-25T02:04:10ZengMDPI AGAntibiotics2079-63822020-03-019312610.3390/antibiotics9030126antibiotics9030126Nonocarbolines A–E, <i>β</i>-Carboline Antibiotics Produced by the Rare Actinobacterium <i>Nonomuraea</i> sp. from IndonesiaGian Primahana0Chandra Risdian1Tjandrawati Mozef2Enge Sudarman3Matthias Köck4Joachim Wink5Marc Stadler6Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124 Braunschweig, GermanyWorking group Microbial Strain Collection, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124 Braunschweig, GermanyResearch Center for Chemistry, Indonesian Institute of Sciences (LIPI), Kawasan Puspiptek, Serpong, 15314 Tangerang Selatan, IndonesiaDepartment Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124 Braunschweig, GermanyAlfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), Am Handelshafen 12, 27570 Bremerhaven, GermanyWorking group Microbial Strain Collection, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124 Braunschweig, GermanyDepartment Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124 Braunschweig, GermanyDuring the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, <i>Nonomuraea</i> sp. 1808210CR was found to produce five unprecedented <i>&#946;</i>-carboline derivatives, nonocarbolines A&#8722;E (<b>1&#8722;5</b>). Their structures were elucidated from high-resolution mass spectrometry, 1D and 2D nuclear magnetic resonance spectroscopy, and the absolute configuration of <b>4</b> was determined by using the modified Mosher method. Nonocarboline B (<b>2</b>) displayed moderate antifungal activity against <i>Mucor hiemalis</i>, while nonocarboline D (<b>4</b>) exhibited significant cytotoxic activity against the human lung carcinoma cell line A-549 with the IC<sub>50</sub> value of 1.7 &#181;M.https://www.mdpi.com/2079-6382/9/3/126<i>nonomuraea</i> sp. 1808210 crrare actinobacteriasecondary metabolite<i>β</i>-carbolines
collection DOAJ
language English
format Article
sources DOAJ
author Gian Primahana
Chandra Risdian
Tjandrawati Mozef
Enge Sudarman
Matthias Köck
Joachim Wink
Marc Stadler
spellingShingle Gian Primahana
Chandra Risdian
Tjandrawati Mozef
Enge Sudarman
Matthias Köck
Joachim Wink
Marc Stadler
Nonocarbolines A–E, <i>β</i>-Carboline Antibiotics Produced by the Rare Actinobacterium <i>Nonomuraea</i> sp. from Indonesia
Antibiotics
<i>nonomuraea</i> sp. 1808210 cr
rare actinobacteria
secondary metabolite
<i>β</i>-carbolines
author_facet Gian Primahana
Chandra Risdian
Tjandrawati Mozef
Enge Sudarman
Matthias Köck
Joachim Wink
Marc Stadler
author_sort Gian Primahana
title Nonocarbolines A–E, <i>β</i>-Carboline Antibiotics Produced by the Rare Actinobacterium <i>Nonomuraea</i> sp. from Indonesia
title_short Nonocarbolines A–E, <i>β</i>-Carboline Antibiotics Produced by the Rare Actinobacterium <i>Nonomuraea</i> sp. from Indonesia
title_full Nonocarbolines A–E, <i>β</i>-Carboline Antibiotics Produced by the Rare Actinobacterium <i>Nonomuraea</i> sp. from Indonesia
title_fullStr Nonocarbolines A–E, <i>β</i>-Carboline Antibiotics Produced by the Rare Actinobacterium <i>Nonomuraea</i> sp. from Indonesia
title_full_unstemmed Nonocarbolines A–E, <i>β</i>-Carboline Antibiotics Produced by the Rare Actinobacterium <i>Nonomuraea</i> sp. from Indonesia
title_sort nonocarbolines a–e, <i>β</i>-carboline antibiotics produced by the rare actinobacterium <i>nonomuraea</i> sp. from indonesia
publisher MDPI AG
series Antibiotics
issn 2079-6382
publishDate 2020-03-01
description During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, <i>Nonomuraea</i> sp. 1808210CR was found to produce five unprecedented <i>&#946;</i>-carboline derivatives, nonocarbolines A&#8722;E (<b>1&#8722;5</b>). Their structures were elucidated from high-resolution mass spectrometry, 1D and 2D nuclear magnetic resonance spectroscopy, and the absolute configuration of <b>4</b> was determined by using the modified Mosher method. Nonocarboline B (<b>2</b>) displayed moderate antifungal activity against <i>Mucor hiemalis</i>, while nonocarboline D (<b>4</b>) exhibited significant cytotoxic activity against the human lung carcinoma cell line A-549 with the IC<sub>50</sub> value of 1.7 &#181;M.
topic <i>nonomuraea</i> sp. 1808210 cr
rare actinobacteria
secondary metabolite
<i>β</i>-carbolines
url https://www.mdpi.com/2079-6382/9/3/126
work_keys_str_mv AT gianprimahana nonocarbolinesaeibicarbolineantibioticsproducedbytherareactinobacteriuminonomuraeaispfromindonesia
AT chandrarisdian nonocarbolinesaeibicarbolineantibioticsproducedbytherareactinobacteriuminonomuraeaispfromindonesia
AT tjandrawatimozef nonocarbolinesaeibicarbolineantibioticsproducedbytherareactinobacteriuminonomuraeaispfromindonesia
AT engesudarman nonocarbolinesaeibicarbolineantibioticsproducedbytherareactinobacteriuminonomuraeaispfromindonesia
AT matthiaskock nonocarbolinesaeibicarbolineantibioticsproducedbytherareactinobacteriuminonomuraeaispfromindonesia
AT joachimwink nonocarbolinesaeibicarbolineantibioticsproducedbytherareactinobacteriuminonomuraeaispfromindonesia
AT marcstadler nonocarbolinesaeibicarbolineantibioticsproducedbytherareactinobacteriuminonomuraeaispfromindonesia
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