Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV

This report describes a case of juvenile myelomonocytic leukaemia (JMML) on a background of both perinatally acquired HIV infection and congenital cytomegalovirus, and management of antiretroviral therapy during haematopoietic stem cell transplant. Peripheral blood HIV viral load remained below the...

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Main Authors:	G. Dobson, N. Klein, P. Veys, W. Qasim, J. Silva, I.L. Cheng, D. Shingadia, G. Tudor-Williams, S.A. Watters, H. Lyall, A. Rao, C. Foster, A. Bamford
Format:	Article
Language:	English
Published:	Elsevier 2019-07-01
Series:	Journal of Virus Eradication
Online Access:	http://www.sciencedirect.com/science/article/pii/S2055664020300480

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spelling	doaj-31cb07f6e3de4d47a227e74d230a5fc62021-05-05T04:04:13ZengElsevierJournal of Virus Eradication2055-66402019-07-0153174177Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIVG. Dobson0N. Klein1P. Veys2W. Qasim3J. Silva4I.L. Cheng5D. Shingadia6G. Tudor-Williams7S.A. Watters8H. Lyall9A. Rao10C. Foster11A. Bamford12Paediatric Infectious Diseases Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UKPaediatric Infectious Diseases Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; UCL Great Ormond Street Institute of Child Health, London, UKUCL Great Ormond Street Institute of Child Health, London, UK; Paediatric Bone Marrow Transplant Department, Great Ormond Street Hospital NHS Foundation Trust, London, UKUCL Great Ormond Street Institute of Child Health, London, UK; Paediatric Immunology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UKPaediatric Bone Marrow Transplant Department, Great Ormond Street Hospital NHS Foundation Trust, London, UKPaediatric Pharmacy Department, Great Ormond Street Hospital NHS Foundation Trust, London, UKPaediatric Infectious Diseases Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; UCL Great Ormond Street Institute of Child Health, London, UKPaediatric Infectious Diseases Department, St Mary's Hospital, Imperial College Healthcare NHS Foundation Trust, London, UK; Division of Infectious Diseases, Imperial College London, London, UKUCL Great Ormond Street Institute of Child Health, London, UKPaediatric Infectious Diseases Department, St Mary's Hospital, Imperial College Healthcare NHS Foundation Trust, London, UKPaediatric Haematology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UKPaediatric Infectious Diseases Department, St Mary's Hospital, Imperial College Healthcare NHS Foundation Trust, London, UKPaediatric Infectious Diseases Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; UCL Great Ormond Street Institute of Child Health, London, UK; Corresponding author: Alasdair Bamford Paediatric Infectious Diseases Department, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UKThis report describes a case of juvenile myelomonocytic leukaemia (JMML) on a background of both perinatally acquired HIV infection and congenital cytomegalovirus, and management of antiretroviral therapy during haematopoietic stem cell transplant. Peripheral blood HIV viral load remained below the lower limit of detection throughout and following transplant and is currently <20 RNA copies/mL. The child is currently in remission from JMML, but HIV DNA remains detectable despite myeloablative conditioning and sustained plasma HIV viral suppression.http://www.sciencedirect.com/science/article/pii/S2055664020300480
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	G. Dobson N. Klein P. Veys W. Qasim J. Silva I.L. Cheng D. Shingadia G. Tudor-Williams S.A. Watters H. Lyall A. Rao C. Foster A. Bamford
spellingShingle	G. Dobson N. Klein P. Veys W. Qasim J. Silva I.L. Cheng D. Shingadia G. Tudor-Williams S.A. Watters H. Lyall A. Rao C. Foster A. Bamford Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV Journal of Virus Eradication
author_facet	G. Dobson N. Klein P. Veys W. Qasim J. Silva I.L. Cheng D. Shingadia G. Tudor-Williams S.A. Watters H. Lyall A. Rao C. Foster A. Bamford
author_sort	G. Dobson
title	Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV
title_short	Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV
title_full	Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV
title_fullStr	Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV
title_full_unstemmed	Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV
title_sort	persistence of hiv reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired hiv
publisher	Elsevier
series	Journal of Virus Eradication
issn	2055-6640
publishDate	2019-07-01
description	This report describes a case of juvenile myelomonocytic leukaemia (JMML) on a background of both perinatally acquired HIV infection and congenital cytomegalovirus, and management of antiretroviral therapy during haematopoietic stem cell transplant. Peripheral blood HIV viral load remained below the lower limit of detection throughout and following transplant and is currently <20 RNA copies/mL. The child is currently in remission from JMML, but HIV DNA remains detectable despite myeloablative conditioning and sustained plasma HIV viral suppression.
url	http://www.sciencedirect.com/science/article/pii/S2055664020300480
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Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV

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