Phytochemicals from Kaempferia angustifolia Rosc. and Their Cytotoxic and Antimicrobial Activities
Phytochemical investigation on rhizomes of Kaempferia angustifolia has afforded a new abietene diterpene, kaempfolienol (1) along with crotepoxide (2), boesenboxide (3), 2′-hydroxy-4,4′,6′-trimethoxychalcone (4), zeylenol (5), 6-methylzeylenol (6), (24S)-24-methyl-5α-lanosta-9(11), 25-dien-3β-ol (7)...
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doaj-31cd53b136664ca4b8653e2428cbc1022020-11-24T21:05:57ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/417674417674Phytochemicals from Kaempferia angustifolia Rosc. and Their Cytotoxic and Antimicrobial ActivitiesSook Wah Tang0Mohd Aspollah Sukari1Bee Keat Neoh2Yunie Soon Yu Yeap3Ahmad Bustamam Abdul4Nurolaini Kifli5Gwendoline Cheng Lian Ee6Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaSime Darby Technology Center, 2 Jalan Tandang, 46050 Petaling Jaya, Selangor, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaUPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaPangiran Anak Puteri Rashidah Sa’adatul Bolkiah Institute of Health Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei DarussalamDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaPhytochemical investigation on rhizomes of Kaempferia angustifolia has afforded a new abietene diterpene, kaempfolienol (1) along with crotepoxide (2), boesenboxide (3), 2′-hydroxy-4,4′,6′-trimethoxychalcone (4), zeylenol (5), 6-methylzeylenol (6), (24S)-24-methyl-5α-lanosta-9(11), 25-dien-3β-ol (7), sucrose, β-sitosterol, and its glycoside (8). The structures of the compounds were elucidated on the basis of spectroscopic methods (IR, MS, and NMR). Isolation of 6-methylzeylenol (6), (24S)-24-methyl-5α-lanosta-9(11), 25-dien-3β-ol (7), and β-sitosterol-3-O-β-D-glucopyranoside (8) from this plant species has never been reported previously. The spectroscopic data of (7) is firstly described in this paper. Cytotoxic screening indicated that most of the pure compounds tested showed significant activity with (4) showing the most potent activity against HL-60 (human promyelocytic leukemia) and MCF-7 (human breast cancer) cell lines. However, all extracts and most of the pure compounds tested were found to be inactive against HT-29 (human colon cancer) and HeLa (human cervical cancer) cell lines. Similarly, none of the extracts or compounds showed activity in the antimicrobial testing.http://dx.doi.org/10.1155/2014/417674 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sook Wah Tang Mohd Aspollah Sukari Bee Keat Neoh Yunie Soon Yu Yeap Ahmad Bustamam Abdul Nurolaini Kifli Gwendoline Cheng Lian Ee |
spellingShingle |
Sook Wah Tang Mohd Aspollah Sukari Bee Keat Neoh Yunie Soon Yu Yeap Ahmad Bustamam Abdul Nurolaini Kifli Gwendoline Cheng Lian Ee Phytochemicals from Kaempferia angustifolia Rosc. and Their Cytotoxic and Antimicrobial Activities BioMed Research International |
author_facet |
Sook Wah Tang Mohd Aspollah Sukari Bee Keat Neoh Yunie Soon Yu Yeap Ahmad Bustamam Abdul Nurolaini Kifli Gwendoline Cheng Lian Ee |
author_sort |
Sook Wah Tang |
title |
Phytochemicals from Kaempferia angustifolia Rosc. and Their Cytotoxic and Antimicrobial Activities |
title_short |
Phytochemicals from Kaempferia angustifolia Rosc. and Their Cytotoxic and Antimicrobial Activities |
title_full |
Phytochemicals from Kaempferia angustifolia Rosc. and Their Cytotoxic and Antimicrobial Activities |
title_fullStr |
Phytochemicals from Kaempferia angustifolia Rosc. and Their Cytotoxic and Antimicrobial Activities |
title_full_unstemmed |
Phytochemicals from Kaempferia angustifolia Rosc. and Their Cytotoxic and Antimicrobial Activities |
title_sort |
phytochemicals from kaempferia angustifolia rosc. and their cytotoxic and antimicrobial activities |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Phytochemical investigation on rhizomes of Kaempferia angustifolia has afforded a new abietene diterpene, kaempfolienol (1) along with crotepoxide (2), boesenboxide (3), 2′-hydroxy-4,4′,6′-trimethoxychalcone (4), zeylenol (5), 6-methylzeylenol (6), (24S)-24-methyl-5α-lanosta-9(11), 25-dien-3β-ol (7), sucrose, β-sitosterol, and its glycoside (8). The structures of the compounds were elucidated on the basis of spectroscopic methods (IR, MS, and NMR). Isolation of 6-methylzeylenol (6), (24S)-24-methyl-5α-lanosta-9(11), 25-dien-3β-ol (7), and β-sitosterol-3-O-β-D-glucopyranoside (8) from this plant species has never been reported previously. The spectroscopic data of (7) is firstly described in this paper. Cytotoxic screening indicated that most of the pure compounds tested showed significant activity with (4) showing the most potent activity against HL-60 (human promyelocytic leukemia) and MCF-7 (human breast cancer) cell lines. However, all extracts and most of the pure compounds tested were found to be inactive against HT-29 (human colon cancer) and HeLa (human cervical cancer) cell lines. Similarly, none of the extracts or compounds showed activity in the antimicrobial testing. |
url |
http://dx.doi.org/10.1155/2014/417674 |
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