Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism

Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism

Ericsson et al. show that different vendors (suppliers of mouse strains) harbor distinct microbiomes, which drive distinct behavioral phenotypes when the genetics are fixed. They specifically focus on changes relating to exploratory and anxiety-related behavior, physiological phenotypic parameters,...

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Main Authors: Aaron C. Ericsson, Marcia L. Hart, Jessica Kwan, Louise Lanoue, Lynette R. Bower, Renee Araiza, K. C. Kent Lloyd, Craig L. Franklin
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02249-0
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spelling doaj-31cee5810a5f4047a8f974fafbfdccee2021-06-13T11:33:39ZengNature Publishing GroupCommunications Biology2399-36422021-06-014111210.1038/s42003-021-02249-0Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolismAaron C. Ericsson0Marcia L. Hart1Jessica Kwan2Louise Lanoue3Lynette R. Bower4Renee Araiza5K. C. Kent Lloyd6Craig L. Franklin7Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri Metagenomics Center (MUMC), University of Missouri (MU)IDEXX BioAnalyticsSchool of Veterinary Medicine, University of California (UC)Mouse Metabolic Phenotyping Center (MMPC) at UC DavisMouse Metabolic Phenotyping Center (MMPC) at UC DavisMouse Metabolic Phenotyping Center (MMPC) at UC DavisMouse Metabolic Phenotyping Center (MMPC) at UC DavisDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri Metagenomics Center (MUMC), University of Missouri (MU)Ericsson et al. show that different vendors (suppliers of mouse strains) harbor distinct microbiomes, which drive distinct behavioral phenotypes when the genetics are fixed. They specifically focus on changes relating to exploratory and anxiety-related behavior, physiological phenotypic parameters, glucose metabolism, and blood leukocytes. They conclude by emphasizing that supplier-origin fecal microbiomes represent potential sources of poor experimental reproducibility and suggest means to optimize experimentation with mice and their microbiomes.https://doi.org/10.1038/s42003-021-02249-0
collection DOAJ
language English
format Article
sources DOAJ
author Aaron C. Ericsson
Marcia L. Hart
Jessica Kwan
Louise Lanoue
Lynette R. Bower
Renee Araiza
K. C. Kent Lloyd
Craig L. Franklin
spellingShingle Aaron C. Ericsson
Marcia L. Hart
Jessica Kwan
Louise Lanoue
Lynette R. Bower
Renee Araiza
K. C. Kent Lloyd
Craig L. Franklin
Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
Communications Biology
author_facet Aaron C. Ericsson
Marcia L. Hart
Jessica Kwan
Louise Lanoue
Lynette R. Bower
Renee Araiza
K. C. Kent Lloyd
Craig L. Franklin
author_sort Aaron C. Ericsson
title Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
title_short Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
title_full Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
title_fullStr Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
title_full_unstemmed Supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
title_sort supplier-origin mouse microbiomes significantly influence locomotor and anxiety-related behavior, body morphology, and metabolism
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-06-01
description Ericsson et al. show that different vendors (suppliers of mouse strains) harbor distinct microbiomes, which drive distinct behavioral phenotypes when the genetics are fixed. They specifically focus on changes relating to exploratory and anxiety-related behavior, physiological phenotypic parameters, glucose metabolism, and blood leukocytes. They conclude by emphasizing that supplier-origin fecal microbiomes represent potential sources of poor experimental reproducibility and suggest means to optimize experimentation with mice and their microbiomes.
url https://doi.org/10.1038/s42003-021-02249-0
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AT jessicakwan supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism
AT louiselanoue supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism
AT lynetterbower supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism
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AT kckentlloyd supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism
AT craiglfranklin supplieroriginmousemicrobiomessignificantlyinfluencelocomotorandanxietyrelatedbehaviorbodymorphologyandmetabolism
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