Proteolytic α-Synuclein Cleavage in Health and Disease

Proteolytic α-Synuclein Cleavage in Health and Disease

In Parkinson’s disease, aggregates of α-synuclein within Lewy bodies and Lewy neurites represent neuropathological hallmarks. However, the cellular and molecular mechanisms triggering oligomeric and fibrillary α-synuclein aggregation are not fully understood. Recent evidence indicates that oxidative...

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Bibliographic Details
Main Authors:	Alexandra Bluhm, Sarah Schrempel, Stephan von Hörsten, Anja Schulze, Steffen Roßner
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	International Journal of Molecular Sciences
Subjects:	α-synuclein post-translational modification proteolysis Parkinson’s disease dementia with Lewy bodies substantia nigra
Online Access:	https://www.mdpi.com/1422-0067/22/11/5450

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