Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients
Guaraná (Paullinia cupana) seeds are rich in flavan-3-ols (catechins) and reduce oxidative stress in humans. We determined the concentration and in vitro bioaccessibility of catechins in guaraná seeds from two geographical origins, and measured their Caco-2 permeability. The effect of macronutrients...
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doaj-32071b2c58a2471cbec70a73f530a8012021-04-30T07:15:51ZengElsevierJournal of Functional Foods1756-46462019-04-0155352361Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrientsThaíse Maria Nogueira Mendes0Yukihisa Murayama1Natsumi Yamaguchi2Geni Rodrigues Sampaio3Luciana Cristina Brigatto Fontes4Elizabeth Aparecida Ferraz da Silva Torres5Hirotoshi Tamura6Lina Yonekura7School of Public Health, University of São Paulo, Av. Dr. Arnaldo 715, São Paulo-SP 03178-200, BrazilFaculty of Agriculture, Kagawa University, 2393 Ikenobe, Miki-cho, Kagawa 761-0795, JapanFaculty of Agriculture, Kagawa University, 2393 Ikenobe, Miki-cho, Kagawa 761-0795, JapanFaculty of Agriculture, Kagawa University, 2393 Ikenobe, Miki-cho, Kagawa 761-0795, JapanSchool of Public Health, University of São Paulo, Av. Dr. Arnaldo 715, São Paulo-SP 03178-200, BrazilSchool of Public Health, University of São Paulo, Av. Dr. Arnaldo 715, São Paulo-SP 03178-200, BrazilFaculty of Agriculture, Kagawa University, 2393 Ikenobe, Miki-cho, Kagawa 761-0795, JapanFaculty of Agriculture, Kagawa University, 2393 Ikenobe, Miki-cho, Kagawa 761-0795, Japan; Corresponding author.Guaraná (Paullinia cupana) seeds are rich in flavan-3-ols (catechins) and reduce oxidative stress in humans. We determined the concentration and in vitro bioaccessibility of catechins in guaraná seeds from two geographical origins, and measured their Caco-2 permeability. The effect of macronutrients on catechins’ bioaccessibility and Caco-2 permeability was also evaluated. Guaraná seeds from southern Bahia and Maués contained, respectively, 30.0 and 26.8 mg catechin/g, 20.2 and 20.0 mg epicatechin/g, 3.7 and 3.8 mg procyanidin B1/g, and 3.3 and 4.9 mg procyanidin B2/g. Bioaccessibility ranged between 65 and 95% for catechin monomers and 50–140% for dimers. Casein inhibited bioaccessibility of catechin dimers, while vegetable oil improved bioaccessibility of total procyanidins. Guaraná catechin monomers and dimers were able to permeate through Caco-2 cell monolayers (Papp 0.31–0.35 × 10−6 cm/s) without effect from co-digested macronutrients. Guaraná seeds are a source of highly bioaccessible catechins, which can permeate the intestinal epithelium with negligible effect from macronutrients.http://www.sciencedirect.com/science/article/pii/S175646461930088XCaco-2 cellsCatechinGuaranáIn vitro digestionMacronutrientsCasein |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thaíse Maria Nogueira Mendes Yukihisa Murayama Natsumi Yamaguchi Geni Rodrigues Sampaio Luciana Cristina Brigatto Fontes Elizabeth Aparecida Ferraz da Silva Torres Hirotoshi Tamura Lina Yonekura |
spellingShingle |
Thaíse Maria Nogueira Mendes Yukihisa Murayama Natsumi Yamaguchi Geni Rodrigues Sampaio Luciana Cristina Brigatto Fontes Elizabeth Aparecida Ferraz da Silva Torres Hirotoshi Tamura Lina Yonekura Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients Journal of Functional Foods Caco-2 cells Catechin Guaraná In vitro digestion Macronutrients Casein |
author_facet |
Thaíse Maria Nogueira Mendes Yukihisa Murayama Natsumi Yamaguchi Geni Rodrigues Sampaio Luciana Cristina Brigatto Fontes Elizabeth Aparecida Ferraz da Silva Torres Hirotoshi Tamura Lina Yonekura |
author_sort |
Thaíse Maria Nogueira Mendes |
title |
Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients |
title_short |
Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients |
title_full |
Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients |
title_fullStr |
Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients |
title_full_unstemmed |
Guaraná (Paullinia cupana) catechins and procyanidins: Gastrointestinal/colonic bioaccessibility, Caco-2 cell permeability and the impact of macronutrients |
title_sort |
guaraná (paullinia cupana) catechins and procyanidins: gastrointestinal/colonic bioaccessibility, caco-2 cell permeability and the impact of macronutrients |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2019-04-01 |
description |
Guaraná (Paullinia cupana) seeds are rich in flavan-3-ols (catechins) and reduce oxidative stress in humans. We determined the concentration and in vitro bioaccessibility of catechins in guaraná seeds from two geographical origins, and measured their Caco-2 permeability. The effect of macronutrients on catechins’ bioaccessibility and Caco-2 permeability was also evaluated. Guaraná seeds from southern Bahia and Maués contained, respectively, 30.0 and 26.8 mg catechin/g, 20.2 and 20.0 mg epicatechin/g, 3.7 and 3.8 mg procyanidin B1/g, and 3.3 and 4.9 mg procyanidin B2/g. Bioaccessibility ranged between 65 and 95% for catechin monomers and 50–140% for dimers. Casein inhibited bioaccessibility of catechin dimers, while vegetable oil improved bioaccessibility of total procyanidins. Guaraná catechin monomers and dimers were able to permeate through Caco-2 cell monolayers (Papp 0.31–0.35 × 10−6 cm/s) without effect from co-digested macronutrients. Guaraná seeds are a source of highly bioaccessible catechins, which can permeate the intestinal epithelium with negligible effect from macronutrients. |
topic |
Caco-2 cells Catechin Guaraná In vitro digestion Macronutrients Casein |
url |
http://www.sciencedirect.com/science/article/pii/S175646461930088X |
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