Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-yl)cinnolines

Synthesis and Biological Activity of Some 3-(4-(Substituted)-piperazin-1-yl)cinnolines

A new series of 6-substituted-4-methyl-3-(4-arylpiperazin-1-yl)cinnolines 8–10 were synthesized as potential antifungal agents via intramolecular cyclization of the respective 1-(2-arylhydrazono)-1-(4-arylpiperazin-1-yl)propan-2-ones 5–7, mediated by polyphosphoric acid (PPA). The amidrazones themse...

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Bibliographic Details
Main Authors: Mohammad S. Mubarak, Randa G. Naffa, Ehab Q. Al-Momani, Malek A. Zihlif, Eman D. Awad, Suzan Matar, Mustafa M. El-Abadelah
Format: Article
Language:English
Published: MDPI AG 2011-12-01
Series:Molecules
Subjects:
hydrazonoyl chlorides
3-(piperazin-1-yl)cinnolines
antitumor and antifungal activity
Online Access:http://www.mdpi.com/1420-3049/17/1/227/

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http://www.mdpi.com/1420-3049/17/1/227/

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