The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
Abstract Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The pos...
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doaj-3216eea292ef41f6b392c5fdaa676d702020-11-25T02:04:08ZengBMCInfectious Agents and Cancer1750-93782018-07-011311610.1186/s13027-018-0194-5The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCCVincenza Granata0Roberta Fusco1Salvatore Filice2Orlando Catalano3Mauro Piccirillo4Raffaele Palaia5Francesco Izzo6Antonella Petrillo7Radiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliHepatobiliary Surgical Oncology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliHepatobiliary Surgical Oncology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliHepatobiliary Surgical Oncology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliAbstract Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.http://link.springer.com/article/10.1186/s13027-018-0194-5HCCMagnetic resonance imagingDiffusion weighted imagingHistologic grade |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vincenza Granata Roberta Fusco Salvatore Filice Orlando Catalano Mauro Piccirillo Raffaele Palaia Francesco Izzo Antonella Petrillo |
spellingShingle |
Vincenza Granata Roberta Fusco Salvatore Filice Orlando Catalano Mauro Piccirillo Raffaele Palaia Francesco Izzo Antonella Petrillo The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC Infectious Agents and Cancer HCC Magnetic resonance imaging Diffusion weighted imaging Histologic grade |
author_facet |
Vincenza Granata Roberta Fusco Salvatore Filice Orlando Catalano Mauro Piccirillo Raffaele Palaia Francesco Izzo Antonella Petrillo |
author_sort |
Vincenza Granata |
title |
The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC |
title_short |
The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC |
title_full |
The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC |
title_fullStr |
The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC |
title_full_unstemmed |
The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC |
title_sort |
current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of hcc |
publisher |
BMC |
series |
Infectious Agents and Cancer |
issn |
1750-9378 |
publishDate |
2018-07-01 |
description |
Abstract Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade. |
topic |
HCC Magnetic resonance imaging Diffusion weighted imaging Histologic grade |
url |
http://link.springer.com/article/10.1186/s13027-018-0194-5 |
work_keys_str_mv |
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