Hepatotropic Properties of SARS-CoV-2—Preliminary Results of Cross-Sectional Observational Study from the First Wave COVID-19 Pandemic
Liver injury—expressed as elevated liver enzymes—is common in patients with COVID-19. Little is known about the potential mechanisms of liver damage by SARS-CoV-2. A direct cytopathic effect on hepatocytes as well as injury related to hypoxia or hepatotoxicity are being considered. The aim of the st...
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MDPI AG
2021-02-01
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Online Access: | https://www.mdpi.com/2077-0383/10/4/672 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hanna Wiśniewska Karolina Skonieczna-Żydecka Miłosz Parczewski Jolanta Niścigorska-Olsen Ewa Karpińska Monika Hornung Krzysztof Jurczyk Magdalena Witak-Jędra Łukasz Laurans Katarzyna Maciejewska Łukasz Socha Agnieszka Leonciuk Dorota Bander Malwina Karasińska-Cieślak Bogusz Aksak-Wąs Marta Wawrzynowicz-Syczewska |
spellingShingle |
Hanna Wiśniewska Karolina Skonieczna-Żydecka Miłosz Parczewski Jolanta Niścigorska-Olsen Ewa Karpińska Monika Hornung Krzysztof Jurczyk Magdalena Witak-Jędra Łukasz Laurans Katarzyna Maciejewska Łukasz Socha Agnieszka Leonciuk Dorota Bander Malwina Karasińska-Cieślak Bogusz Aksak-Wąs Marta Wawrzynowicz-Syczewska Hepatotropic Properties of SARS-CoV-2—Preliminary Results of Cross-Sectional Observational Study from the First Wave COVID-19 Pandemic Journal of Clinical Medicine COVID-19 SARS-CoV-2 infection liver enzyme abnormality liver dysfunction |
author_facet |
Hanna Wiśniewska Karolina Skonieczna-Żydecka Miłosz Parczewski Jolanta Niścigorska-Olsen Ewa Karpińska Monika Hornung Krzysztof Jurczyk Magdalena Witak-Jędra Łukasz Laurans Katarzyna Maciejewska Łukasz Socha Agnieszka Leonciuk Dorota Bander Malwina Karasińska-Cieślak Bogusz Aksak-Wąs Marta Wawrzynowicz-Syczewska |
author_sort |
Hanna Wiśniewska |
title |
Hepatotropic Properties of SARS-CoV-2—Preliminary Results of Cross-Sectional Observational Study from the First Wave COVID-19 Pandemic |
title_short |
Hepatotropic Properties of SARS-CoV-2—Preliminary Results of Cross-Sectional Observational Study from the First Wave COVID-19 Pandemic |
title_full |
Hepatotropic Properties of SARS-CoV-2—Preliminary Results of Cross-Sectional Observational Study from the First Wave COVID-19 Pandemic |
title_fullStr |
Hepatotropic Properties of SARS-CoV-2—Preliminary Results of Cross-Sectional Observational Study from the First Wave COVID-19 Pandemic |
title_full_unstemmed |
Hepatotropic Properties of SARS-CoV-2—Preliminary Results of Cross-Sectional Observational Study from the First Wave COVID-19 Pandemic |
title_sort |
hepatotropic properties of sars-cov-2—preliminary results of cross-sectional observational study from the first wave covid-19 pandemic |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-02-01 |
description |
Liver injury—expressed as elevated liver enzymes—is common in patients with COVID-19. Little is known about the potential mechanisms of liver damage by SARS-CoV-2. A direct cytopathic effect on hepatocytes as well as injury related to hypoxia or hepatotoxicity are being considered. The aim of the study was to compare the clinical characteristic of COVID-19 disease in patients with normal and abnormal liver enzymes activity. A group of 150 patients with COVID-19, hospitalized in our center, was analyzed. Patients with the known liver comorbidities were excluded (<i>n</i> = 15). Clinical features and laboratory parameters were compared between patients with normal and abnormal aminotransferase values. Liver injury expressed as any alanine aminotransferase (ALT) elevation was noted in 45.6% of patients hospitalized due to COVID-19. The frequencies of aspartate aminotransferase (AST) elevation were lower. It was noted that elevated ALT/AST unfavorably affected other parameters related to liver function such as albumin level; gamma-glutamyl transpeptidase (GGTP); and partly, ALP activity and influenced inflammation-related parameters. The most probable cause of mild hepatitis during COVID-19 was anoxia and immune-mediated damage due to the inflammatory response following SARS-CoV-2 infection. A direct cytopathic effect of SARS-CoV-2 on hepatocytes, albeit less probable, can be considered as well. The use of potentially hepatotoxic drugs may contribute to liver damage. |
topic |
COVID-19 SARS-CoV-2 infection liver enzyme abnormality liver dysfunction |
url |
https://www.mdpi.com/2077-0383/10/4/672 |
work_keys_str_mv |
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doaj-3221d6cd67934d579b9c9d89b2ef85222021-02-10T00:06:07ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-011067267210.3390/jcm10040672Hepatotropic Properties of SARS-CoV-2—Preliminary Results of Cross-Sectional Observational Study from the First Wave COVID-19 PandemicHanna Wiśniewska0Karolina Skonieczna-Żydecka1Miłosz Parczewski2Jolanta Niścigorska-Olsen3Ewa Karpińska4Monika Hornung5Krzysztof Jurczyk6Magdalena Witak-Jędra7Łukasz Laurans8Katarzyna Maciejewska9Łukasz Socha10Agnieszka Leonciuk11Dorota Bander12Malwina Karasińska-Cieślak13Bogusz Aksak-Wąs14Marta Wawrzynowicz-Syczewska15Department of Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Biochemical Sciences, Pomeranian Medical University, 71-460 Szczecin, PolandDepartment of Infectious, Tropical Diseases, and Immune Deficiency, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious, Tropical Diseases, and Immune Deficiency, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious, Tropical Diseases, and Immune Deficiency, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious, Tropical Diseases, and Immune Deficiency, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious, Tropical Diseases, and Immune Deficiency, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious, Tropical Diseases, and Immune Deficiency, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious, Tropical Diseases, and Immune Deficiency, Pomeranian Medical University, 71-455 Szczecin, PolandDepartment of Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, 71-455 Szczecin, PolandLiver injury—expressed as elevated liver enzymes—is common in patients with COVID-19. Little is known about the potential mechanisms of liver damage by SARS-CoV-2. A direct cytopathic effect on hepatocytes as well as injury related to hypoxia or hepatotoxicity are being considered. The aim of the study was to compare the clinical characteristic of COVID-19 disease in patients with normal and abnormal liver enzymes activity. A group of 150 patients with COVID-19, hospitalized in our center, was analyzed. Patients with the known liver comorbidities were excluded (<i>n</i> = 15). Clinical features and laboratory parameters were compared between patients with normal and abnormal aminotransferase values. Liver injury expressed as any alanine aminotransferase (ALT) elevation was noted in 45.6% of patients hospitalized due to COVID-19. The frequencies of aspartate aminotransferase (AST) elevation were lower. It was noted that elevated ALT/AST unfavorably affected other parameters related to liver function such as albumin level; gamma-glutamyl transpeptidase (GGTP); and partly, ALP activity and influenced inflammation-related parameters. The most probable cause of mild hepatitis during COVID-19 was anoxia and immune-mediated damage due to the inflammatory response following SARS-CoV-2 infection. A direct cytopathic effect of SARS-CoV-2 on hepatocytes, albeit less probable, can be considered as well. The use of potentially hepatotoxic drugs may contribute to liver damage.https://www.mdpi.com/2077-0383/10/4/672COVID-19SARS-CoV-2 infectionliver enzyme abnormalityliver dysfunction |