Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2
Suryamohan, Diwanji, Stawiski et al. identify natural ACE2 variants that are predicted to alter virus–host interactions. They find that soluble ACE2 K26R and T92I variants are more effective in blocking the entry of SARS-CoV-2 S-protein pseudotyped virus, compared to wild-type ACE2. This study sugge...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02030-3 |
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doaj-32225ac91a454b1683c6a373e209aa042021-04-18T11:29:53ZengNature Publishing GroupCommunications Biology2399-36422021-04-014111110.1038/s42003-021-02030-3Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2Kushal Suryamohan0Devan Diwanji1Eric W. Stawiski2Ravi Gupta3Shane Miersch4Jiang Liu5Chao Chen6Ying-Ping Jiang7Frederic A. Fellouse8J. Fah Sathirapongsasuti9Patrick K. Albers10Tanneeru Deepak11Reza Saberianfar12Aakrosh Ratan13Gavin Washburn14Monika Mis15Devi Santhosh16Sneha Somasekar17G. H. Hiranjith18Derek Vargas19Sangeetha Mohan20Sameer Phalke21Boney Kuriakose22Aju Antony23Mart Ustav Jr24Stephan C. Schuster25Sachdev Sidhu26Jagath R. Junutula27Natalia Jura28Somasekar Seshagiri29Research and Development Department, MedGenome IncCardiovascular Research Institute, University of California San FranciscoResearch and Development Department, MedGenome IncMedGenome Labs Ltd.Department of Molecular Genetics, and the Terrence Donnelly Center for Cellular and Biomolecular Research, University of TorontoModMab TherapeuticsDepartment of Molecular Genetics, and the Terrence Donnelly Center for Cellular and Biomolecular Research, University of TorontoModMab TherapeuticsModMab Therapeutics, Accelerator for Donnelly Collaboration, University of TorontoResearch and Development Department, MedGenome IncWellcome Sanger InstituteMedGenome Labs Ltd.ModMab Therapeutics, Accelerator for Donnelly Collaboration, University of TorontoCenter for Public Health Genomics, University of VirginiaResearch and Development Department, MedGenome IncResearch and Development Department, MedGenome IncModMab TherapeuticsMidwestern UniversityResearch and Development Department, MedGenome IncResearch and Development Department, MedGenome IncDepartment of Molecular Biology, SciGenom Labs Pvt LtdDepartment of Molecular Biology, SciGenom Labs Pvt LtdAgriGenome Labs Private LtdDepartment of Molecular Biology, SciGenom Labs Pvt LtdDepartment of Molecular Genetics, and the Terrence Donnelly Center for Cellular and Biomolecular Research, University of TorontoSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological UniversityDepartment of Molecular Genetics, and the Terrence Donnelly Center for Cellular and Biomolecular Research, University of TorontoModMab TherapeuticsCardiovascular Research Institute, University of California San FranciscoModMab TherapeuticsSuryamohan, Diwanji, Stawiski et al. identify natural ACE2 variants that are predicted to alter virus–host interactions. They find that soluble ACE2 K26R and T92I variants are more effective in blocking the entry of SARS-CoV-2 S-protein pseudotyped virus, compared to wild-type ACE2. This study suggests that ACE2 variants may modulate the host susceptibility to SARS-CoV-2.https://doi.org/10.1038/s42003-021-02030-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kushal Suryamohan Devan Diwanji Eric W. Stawiski Ravi Gupta Shane Miersch Jiang Liu Chao Chen Ying-Ping Jiang Frederic A. Fellouse J. Fah Sathirapongsasuti Patrick K. Albers Tanneeru Deepak Reza Saberianfar Aakrosh Ratan Gavin Washburn Monika Mis Devi Santhosh Sneha Somasekar G. H. Hiranjith Derek Vargas Sangeetha Mohan Sameer Phalke Boney Kuriakose Aju Antony Mart Ustav Jr Stephan C. Schuster Sachdev Sidhu Jagath R. Junutula Natalia Jura Somasekar Seshagiri |
| spellingShingle |
Kushal Suryamohan Devan Diwanji Eric W. Stawiski Ravi Gupta Shane Miersch Jiang Liu Chao Chen Ying-Ping Jiang Frederic A. Fellouse J. Fah Sathirapongsasuti Patrick K. Albers Tanneeru Deepak Reza Saberianfar Aakrosh Ratan Gavin Washburn Monika Mis Devi Santhosh Sneha Somasekar G. H. Hiranjith Derek Vargas Sangeetha Mohan Sameer Phalke Boney Kuriakose Aju Antony Mart Ustav Jr Stephan C. Schuster Sachdev Sidhu Jagath R. Junutula Natalia Jura Somasekar Seshagiri Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2 Communications Biology |
| author_facet |
Kushal Suryamohan Devan Diwanji Eric W. Stawiski Ravi Gupta Shane Miersch Jiang Liu Chao Chen Ying-Ping Jiang Frederic A. Fellouse J. Fah Sathirapongsasuti Patrick K. Albers Tanneeru Deepak Reza Saberianfar Aakrosh Ratan Gavin Washburn Monika Mis Devi Santhosh Sneha Somasekar G. H. Hiranjith Derek Vargas Sangeetha Mohan Sameer Phalke Boney Kuriakose Aju Antony Mart Ustav Jr Stephan C. Schuster Sachdev Sidhu Jagath R. Junutula Natalia Jura Somasekar Seshagiri |
| author_sort |
Kushal Suryamohan |
| title |
Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2 |
| title_short |
Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2 |
| title_full |
Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2 |
| title_fullStr |
Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2 |
| title_full_unstemmed |
Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2 |
| title_sort |
human ace2 receptor polymorphisms and altered susceptibility to sars-cov-2 |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-04-01 |
| description |
Suryamohan, Diwanji, Stawiski et al. identify natural ACE2 variants that are predicted to alter virus–host interactions. They find that soluble ACE2 K26R and T92I variants are more effective in blocking the entry of SARS-CoV-2 S-protein pseudotyped virus, compared to wild-type ACE2. This study suggests that ACE2 variants may modulate the host susceptibility to SARS-CoV-2. |
| url |
https://doi.org/10.1038/s42003-021-02030-3 |
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