How useful is esophageal high resolution manometry in diagnosing gastroesophageal junction disruption: causes affecting this disruption and its relationship with manometric alterations and gastroesophageal reflux
Background: High-resolution manometry (HRM) is a breakthrough in the morphological study of the gastroesophageal junction (GEJ) and its degrees of disruption. Objectives: a) Assessment of risk factors involved in the disruption of the GEJ in patients with gastroesophageal reflux (GER) symptoms; b) t...
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doaj-3230542574404c099662ba720a98c0532020-11-24T22:42:26ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01082014-01-011061222910.4321/s1130-01082014000100004S1130-01082014000100004How useful is esophageal high resolution manometry in diagnosing gastroesophageal junction disruption: causes affecting this disruption and its relationship with manometric alterations and gastroesophageal refluxConstanza Ciriza-de-los-Ríos0Fernando Canga-Rodríguez-Valcárcel1Isabel Castel-de-Lucas2David Lora-Pablos3Javier de-la-Cruz-Bértolo4Gregorio Castellano-Tortajada5Hospital Universitario 12 de OctubreHospital Universitario 12 de OctubreHospital Universitario 12 de OctubreCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP)Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP)Hospital Universitario 12 de OctubreBackground: High-resolution manometry (HRM) is a breakthrough in the morphological study of the gastroesophageal junction (GEJ) and its degrees of disruption. Objectives: a) Assessment of risk factors involved in the disruption of the GEJ in patients with gastroesophageal reflux (GER) symptoms; b) the relationship between the type of GEJ and GER demonstrated by 24 hours pH-monitoring; and c) identification of the alterations in the manometric parameters related to the morphology of the GEJ. Methods: One hundred and fifteen patients with symptoms of GER studied with HRM and classified by the type of GEJ (type I: Normal; type II: Sliding; type III: Hiatal hernia). Twenty four hour pH-monitoring without proton pump inhibitors was performed in all of them. Epidemiological aspects, manometric parameters (Chicago 2012 classification) and the pH-monitoring results were evaluated. Results: Age (OR 1.033 [1.006-1.060]; p = 0.16), BMI (OR 1.097 [1.022-1.176]; p = 0. 01) and abdominal perimeter (OR 1.034 [1.005-1.063]; p = 0.0215) were independent risk factors for the GEJ type III (area under the curve 0.70). Disruption of the GEJ was associated with a lower resting pressure (p = 0.006), greater length (p < 0.001) and greater esophageal shortening (p < 0.001). Abnormal acidic reflux was found in the total period (p = 0.015), standing (p = 0.022) and supine (p = 0.001) in patients with GEJ type II and III with respect to type I. Conclusions: Increased age, overweight and central obesity pose a higher risk of GEJ type III (hiatal hernia). The greater disruption of the GEJ is associated with lower resting pressure, esophageal shortening, and higher acid exposure in the pH-monitoring.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082014000100004&lng=en&tlng=enManometría esofágica de alta resoluciónUnión gastroesofágicaHernia de hiatoReflujo gastroesofágico |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Constanza Ciriza-de-los-Ríos Fernando Canga-Rodríguez-Valcárcel Isabel Castel-de-Lucas David Lora-Pablos Javier de-la-Cruz-Bértolo Gregorio Castellano-Tortajada |
spellingShingle |
Constanza Ciriza-de-los-Ríos Fernando Canga-Rodríguez-Valcárcel Isabel Castel-de-Lucas David Lora-Pablos Javier de-la-Cruz-Bértolo Gregorio Castellano-Tortajada How useful is esophageal high resolution manometry in diagnosing gastroesophageal junction disruption: causes affecting this disruption and its relationship with manometric alterations and gastroesophageal reflux Revista Espanola de Enfermedades Digestivas Manometría esofágica de alta resolución Unión gastroesofágica Hernia de hiato Reflujo gastroesofágico |
author_facet |
Constanza Ciriza-de-los-Ríos Fernando Canga-Rodríguez-Valcárcel Isabel Castel-de-Lucas David Lora-Pablos Javier de-la-Cruz-Bértolo Gregorio Castellano-Tortajada |
author_sort |
Constanza Ciriza-de-los-Ríos |
title |
How useful is esophageal high resolution manometry in diagnosing gastroesophageal junction disruption: causes affecting this disruption and its relationship with manometric alterations and gastroesophageal reflux |
title_short |
How useful is esophageal high resolution manometry in diagnosing gastroesophageal junction disruption: causes affecting this disruption and its relationship with manometric alterations and gastroesophageal reflux |
title_full |
How useful is esophageal high resolution manometry in diagnosing gastroesophageal junction disruption: causes affecting this disruption and its relationship with manometric alterations and gastroesophageal reflux |
title_fullStr |
How useful is esophageal high resolution manometry in diagnosing gastroesophageal junction disruption: causes affecting this disruption and its relationship with manometric alterations and gastroesophageal reflux |
title_full_unstemmed |
How useful is esophageal high resolution manometry in diagnosing gastroesophageal junction disruption: causes affecting this disruption and its relationship with manometric alterations and gastroesophageal reflux |
title_sort |
how useful is esophageal high resolution manometry in diagnosing gastroesophageal junction disruption: causes affecting this disruption and its relationship with manometric alterations and gastroesophageal reflux |
publisher |
Aran Ediciones |
series |
Revista Espanola de Enfermedades Digestivas |
issn |
1130-0108 |
publishDate |
2014-01-01 |
description |
Background: High-resolution manometry (HRM) is a breakthrough in the morphological study of the gastroesophageal junction (GEJ) and its degrees of disruption. Objectives: a) Assessment of risk factors involved in the disruption of the GEJ in patients with gastroesophageal reflux (GER) symptoms; b) the relationship between the type of GEJ and GER demonstrated by 24 hours pH-monitoring; and c) identification of the alterations in the manometric parameters related to the morphology of the GEJ. Methods: One hundred and fifteen patients with symptoms of GER studied with HRM and classified by the type of GEJ (type I: Normal; type II: Sliding; type III: Hiatal hernia). Twenty four hour pH-monitoring without proton pump inhibitors was performed in all of them. Epidemiological aspects, manometric parameters (Chicago 2012 classification) and the pH-monitoring results were evaluated. Results: Age (OR 1.033 [1.006-1.060]; p = 0.16), BMI (OR 1.097 [1.022-1.176]; p = 0. 01) and abdominal perimeter (OR 1.034 [1.005-1.063]; p = 0.0215) were independent risk factors for the GEJ type III (area under the curve 0.70). Disruption of the GEJ was associated with a lower resting pressure (p = 0.006), greater length (p < 0.001) and greater esophageal shortening (p < 0.001). Abnormal acidic reflux was found in the total period (p = 0.015), standing (p = 0.022) and supine (p = 0.001) in patients with GEJ type II and III with respect to type I. Conclusions: Increased age, overweight and central obesity pose a higher risk of GEJ type III (hiatal hernia). The greater disruption of the GEJ is associated with lower resting pressure, esophageal shortening, and higher acid exposure in the pH-monitoring. |
topic |
Manometría esofágica de alta resolución Unión gastroesofágica Hernia de hiato Reflujo gastroesofágico |
url |
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082014000100004&lng=en&tlng=en |
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