Mechanical Regulation of Cardiac Development
Mechanical forces are an essential contributor to and unavoidable component of cardiac formation, both inducing and orchestrating local and global molecular and cellular changes. Experimental animal studies have contributed substantially to understanding the mechanobiology of heart development. More...
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2014-08-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00318/full |
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doaj-323317f34f5a42a8881c9caddb3f3e8c2020-11-25T01:12:46ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2014-08-01510.3389/fphys.2014.00318100773Mechanical Regulation of Cardiac DevelopmentStephanie E Lindsey0Jonathan T Butcher1Huseyin Cagatay Yalcin2Cornell UniversityCornell UniversityDogus UniversityMechanical forces are an essential contributor to and unavoidable component of cardiac formation, both inducing and orchestrating local and global molecular and cellular changes. Experimental animal studies have contributed substantially to understanding the mechanobiology of heart development. More recent integration of high-resolution imaging modalities with computational modeling has greatly improved our quantitative understanding of hemodynamic flow in heart development. Merging these latest experimental technologies with molecular and genetic signaling analysis will accelerate our understanding of the relationships integrating mechanical and biological signaling for proper cardiac formation. These advances will likely be essential for clinically translatable guidance for targeted interventions to rescue malforming hearts and/or reconfigure malformed circulations for optimal performance. This review summarizes our current understanding on the levels of mechanical signaling in the heart and their roles in orchestrating cardiac development.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00318/fullHemodynamicsMechanotransductionshear stresscongenital heart defectsheart development |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stephanie E Lindsey Jonathan T Butcher Huseyin Cagatay Yalcin |
spellingShingle |
Stephanie E Lindsey Jonathan T Butcher Huseyin Cagatay Yalcin Mechanical Regulation of Cardiac Development Frontiers in Physiology Hemodynamics Mechanotransduction shear stress congenital heart defects heart development |
author_facet |
Stephanie E Lindsey Jonathan T Butcher Huseyin Cagatay Yalcin |
author_sort |
Stephanie E Lindsey |
title |
Mechanical Regulation of Cardiac Development |
title_short |
Mechanical Regulation of Cardiac Development |
title_full |
Mechanical Regulation of Cardiac Development |
title_fullStr |
Mechanical Regulation of Cardiac Development |
title_full_unstemmed |
Mechanical Regulation of Cardiac Development |
title_sort |
mechanical regulation of cardiac development |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2014-08-01 |
description |
Mechanical forces are an essential contributor to and unavoidable component of cardiac formation, both inducing and orchestrating local and global molecular and cellular changes. Experimental animal studies have contributed substantially to understanding the mechanobiology of heart development. More recent integration of high-resolution imaging modalities with computational modeling has greatly improved our quantitative understanding of hemodynamic flow in heart development. Merging these latest experimental technologies with molecular and genetic signaling analysis will accelerate our understanding of the relationships integrating mechanical and biological signaling for proper cardiac formation. These advances will likely be essential for clinically translatable guidance for targeted interventions to rescue malforming hearts and/or reconfigure malformed circulations for optimal performance. This review summarizes our current understanding on the levels of mechanical signaling in the heart and their roles in orchestrating cardiac development. |
topic |
Hemodynamics Mechanotransduction shear stress congenital heart defects heart development |
url |
http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00318/full |
work_keys_str_mv |
AT stephanieelindsey mechanicalregulationofcardiacdevelopment AT jonathantbutcher mechanicalregulationofcardiacdevelopment AT huseyincagatayyalcin mechanicalregulationofcardiacdevelopment |
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1725165068788695040 |