Integrins: An Important Link between Angiogenesis, Inflammation and Eye Diseases
Integrins belong to a group of cell adhesion molecules (CAMs) which is a large group of membrane-bound proteins. They are responsible for cell attachment to the extracellular matrix (ECM) and signal transduction from the ECM to the cells. Integrins take part in many other biological activities, such...
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doaj-32351b45f0d24e25b8a850d1266ffb402021-07-23T13:34:55ZengMDPI AGCells2073-44092021-07-01101703170310.3390/cells10071703Integrins: An Important Link between Angiogenesis, Inflammation and Eye DiseasesMałgorzata Mrugacz0Anna Bryl1Mariusz Falkowski2Katarzyna Zorena3Department of Ophthalmology and Eye Rehabilitation, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Ophthalmology and Eye Rehabilitation, Medical University of Bialystok, 15-089 Bialystok, PolandMedical University of Bialystok, 15-089 Bialystok, PolandDepartment of Immunobiology and Environmental Microbiology, Medical University of Gdansk, 80-211 Gdansk, PolandIntegrins belong to a group of cell adhesion molecules (CAMs) which is a large group of membrane-bound proteins. They are responsible for cell attachment to the extracellular matrix (ECM) and signal transduction from the ECM to the cells. Integrins take part in many other biological activities, such as extravasation, cell-to-cell adhesion, migration, cytokine activation and release, and act as receptors for some viruses, including severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). They play a pivotal role in cell proliferation, migration, apoptosis, tissue repair and are involved in the processes that are crucial to infection, inflammation and angiogenesis. Integrins have an important part in normal development and tissue homeostasis, and also in the development of pathological processes in the eye. This review presents the available evidence from human and animal research into integrin structure, classification, function and their role in inflammation, infection and angiogenesis in ocular diseases. Integrin receptors and ligands are clinically interesting and may be promising as new therapeutic targets in the treatment of some eye disorders.https://www.mdpi.com/2073-4409/10/7/1703integrinseyecorneadry eye diseasecataractglaucoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Małgorzata Mrugacz Anna Bryl Mariusz Falkowski Katarzyna Zorena |
spellingShingle |
Małgorzata Mrugacz Anna Bryl Mariusz Falkowski Katarzyna Zorena Integrins: An Important Link between Angiogenesis, Inflammation and Eye Diseases Cells integrins eye cornea dry eye disease cataract glaucoma |
author_facet |
Małgorzata Mrugacz Anna Bryl Mariusz Falkowski Katarzyna Zorena |
author_sort |
Małgorzata Mrugacz |
title |
Integrins: An Important Link between Angiogenesis, Inflammation and Eye Diseases |
title_short |
Integrins: An Important Link between Angiogenesis, Inflammation and Eye Diseases |
title_full |
Integrins: An Important Link between Angiogenesis, Inflammation and Eye Diseases |
title_fullStr |
Integrins: An Important Link between Angiogenesis, Inflammation and Eye Diseases |
title_full_unstemmed |
Integrins: An Important Link between Angiogenesis, Inflammation and Eye Diseases |
title_sort |
integrins: an important link between angiogenesis, inflammation and eye diseases |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2021-07-01 |
description |
Integrins belong to a group of cell adhesion molecules (CAMs) which is a large group of membrane-bound proteins. They are responsible for cell attachment to the extracellular matrix (ECM) and signal transduction from the ECM to the cells. Integrins take part in many other biological activities, such as extravasation, cell-to-cell adhesion, migration, cytokine activation and release, and act as receptors for some viruses, including severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). They play a pivotal role in cell proliferation, migration, apoptosis, tissue repair and are involved in the processes that are crucial to infection, inflammation and angiogenesis. Integrins have an important part in normal development and tissue homeostasis, and also in the development of pathological processes in the eye. This review presents the available evidence from human and animal research into integrin structure, classification, function and their role in inflammation, infection and angiogenesis in ocular diseases. Integrin receptors and ligands are clinically interesting and may be promising as new therapeutic targets in the treatment of some eye disorders. |
topic |
integrins eye cornea dry eye disease cataract glaucoma |
url |
https://www.mdpi.com/2073-4409/10/7/1703 |
work_keys_str_mv |
AT małgorzatamrugacz integrinsanimportantlinkbetweenangiogenesisinflammationandeyediseases AT annabryl integrinsanimportantlinkbetweenangiogenesisinflammationandeyediseases AT mariuszfalkowski integrinsanimportantlinkbetweenangiogenesisinflammationandeyediseases AT katarzynazorena integrinsanimportantlinkbetweenangiogenesisinflammationandeyediseases |
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1721288978147049472 |