Increased myofibroblasts in the small airways, and relationship to remodelling and functional changes in smokers and COPD patients: potential role of epithelial–mesenchymal transition

Increased myofibroblasts in the small airways, and relationship to remodelling and functional changes in smokers and COPD patients: potential role of epithelial–mesenchymal transition

Introduction Previous reports have shown epithelial–mesenchymal transition (EMT) as an active process that contributes to small airway fibrotic pathology. Myofibroblasts are highly active pro-fibrotic cells that secrete excessive and altered extracellular matrix (ECM). Here we relate small airway my...

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Bibliographic Details
Main Authors: Mathew Suji Eapen, Wenying Lu, Tillie L. Hackett, Gurpreet Kaur Singhera, Malik Q. Mahmood, Ashutosh Hardikar, Chris Ward, Eugene Haydn Walters, Sukhwinder Singh Sohal
Format: Article
Language:English
Published: European Respiratory Society 2021-06-01
Series:ERJ Open Research
Online Access:http://openres.ersjournals.com/content/7/2/00876-2020.full

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http://openres.ersjournals.com/content/7/2/00876-2020.full

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