A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine

A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine

Gut organoids are stem cell derived 3D models of the intestinal epithelium that are useful for studying interactions between enteric pathogens and their host. While the organoid model has been used for both bacterial and viral infections, this is a closed system with the luminal side being inaccessi...

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Bibliographic Details
Main Authors: Thomas Roodsant, Marit Navis, Ikrame Aknouch, Ingrid B. Renes, Ruurd M. van Elburg, Dasja Pajkrt, Katja C. Wolthers, Constance Schultsz, Kees C. H. van der Ark, Adithya Sridhar, Vanesa Muncan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
human organoids
small intestine
enteric pathogens
polarized epithelium
host-pathogen interactions
gut barrier
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00272/full

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https://www.frontiersin.org/article/10.3389/fcimb.2020.00272/full

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