Alveolar Dynamics and Beyond – The Importance of Surfactant Protein C and Cholesterol in Lung Homeostasis and Fibrosis

Alveolar Dynamics and Beyond – The Importance of Surfactant Protein C and Cholesterol in Lung Homeostasis and Fibrosis

Surfactant protein C (SP-C) is an important player in enhancing the interfacial adsorption of lung surfactant lipid films to the alveolar air-liquid interface. Doing so, surface tension drops down enough to stabilize alveoli and the lung, reducing the work of breathing. In addition, it has been show...

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Bibliographic Details
Main Authors: Kirsten Sehlmeyer, Jannik Ruwisch, Nuria Roldan, Elena Lopez-Rodriguez
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
surfactant protein C
pulmonary fibrosis
alveolar dynamics
lipid metabolism
alveolar macrophages
cholesterol
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00386/full

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