Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin
The study aims to map plasma gelsolin (pGSN) levels in diabetic humans and mice models of type II diabetes and to evaluate the efficacy of gelsolin therapy in improvement of diabetes in mice. We report that pGSN values decrease by a factor of 0.45 to 0.5 in the blood of type II diabetic humans and m...
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doaj-326acf7b3f0d4148bd9eef0a5a47fb902020-11-25T01:28:24ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/152075152075Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of GelsolinNeeraj Khatri0Amin Sagar1Nagesh Peddada2Vikas Choudhary3Bhupinder Singh Chopra4Veena Garg5Renu Garg6Ashish7CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, IndiaCSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, IndiaCSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, IndiaCSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, IndiaCSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, IndiaDepartment of Bioscience and Biotechnology, Banasthali University, Rajasthan 304022, IndiaCSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, IndiaCSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh 160036, IndiaThe study aims to map plasma gelsolin (pGSN) levels in diabetic humans and mice models of type II diabetes and to evaluate the efficacy of gelsolin therapy in improvement of diabetes in mice. We report that pGSN values decrease by a factor of 0.45 to 0.5 in the blood of type II diabetic humans and mice models. Oral glucose tolerance test in mice models showed that subcutaneous administration of recombinant pGSN and its F-actin depolymerizing competent versions brought down blood sugar levels comparable to Sitagliptin, a drug used to manage hyperglycemic condition. Further, daily dose of pGSN or its truncated versions to diabetic mice for a week kept sugar levels close to normal values. Also, diabetic mice treated with Sitagliptin for 7 days, showed increase in their pGSN values with the decrease in blood glucose as compared to their levels at the start of treatment. Gelsolin helped in improving glycemic control in diabetic mice. We propose that gelsolin level monitoring and replacement of F-actin severing capable gelsolin(s) should be considered in diabetic care.http://dx.doi.org/10.1155/2014/152075 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Neeraj Khatri Amin Sagar Nagesh Peddada Vikas Choudhary Bhupinder Singh Chopra Veena Garg Renu Garg Ashish |
spellingShingle |
Neeraj Khatri Amin Sagar Nagesh Peddada Vikas Choudhary Bhupinder Singh Chopra Veena Garg Renu Garg Ashish Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin Journal of Diabetes Research |
author_facet |
Neeraj Khatri Amin Sagar Nagesh Peddada Vikas Choudhary Bhupinder Singh Chopra Veena Garg Renu Garg Ashish |
author_sort |
Neeraj Khatri |
title |
Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin |
title_short |
Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin |
title_full |
Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin |
title_fullStr |
Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin |
title_full_unstemmed |
Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin |
title_sort |
plasma gelsolin levels decrease in diabetic state and increase upon treatment with f-actin depolymerizing versions of gelsolin |
publisher |
Hindawi Limited |
series |
Journal of Diabetes Research |
issn |
2314-6745 2314-6753 |
publishDate |
2014-01-01 |
description |
The study aims to map plasma gelsolin (pGSN) levels in diabetic humans and mice models of type II diabetes and to evaluate the efficacy of gelsolin therapy in improvement of diabetes in mice. We report that pGSN values decrease by a factor of 0.45 to 0.5 in the blood of type II diabetic humans and mice models. Oral glucose tolerance test in mice models showed that subcutaneous administration of recombinant pGSN and its F-actin depolymerizing competent versions brought down blood sugar levels comparable to Sitagliptin, a drug used to manage hyperglycemic condition. Further, daily dose of pGSN or its truncated versions to diabetic mice for a week kept sugar levels close to normal values. Also, diabetic mice treated with Sitagliptin for 7 days, showed increase in their pGSN values with the decrease in blood glucose as compared to their levels at the start of treatment. Gelsolin helped in improving glycemic control in diabetic mice. We propose that gelsolin level monitoring and replacement of F-actin severing capable gelsolin(s) should be considered in diabetic care. |
url |
http://dx.doi.org/10.1155/2014/152075 |
work_keys_str_mv |
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