Subcutaneous autologous serum therapy in chronic spontaneous urticaria
Background: There is a felt need for trying newer therapeutic modalities in patients with chronic spontaneous urticaria, especially in the subset of patients classified as non-responders to antihistamines. Autologous serum therapy is an upcoming modality of treatment, and we decided to study its eff...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2017-01-01
|
Series: | Indian Journal of Dermatology |
Subjects: | |
Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2017;volume=62;issue=5;spage=505;epage=507;aulast=Godse |
id |
doaj-32770393e77a4e648e96f8420c05c599 |
---|---|
record_format |
Article |
spelling |
doaj-32770393e77a4e648e96f8420c05c5992020-11-25T01:05:53ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112017-01-0162550550710.4103/ijd.IJD_710_16Subcutaneous autologous serum therapy in chronic spontaneous urticariaKiran Vasant GodseNitin NadkarniSharmila PatilAayushi MehtaBackground: There is a felt need for trying newer therapeutic modalities in patients with chronic spontaneous urticaria, especially in the subset of patients classified as non-responders to antihistamines. Autologous serum therapy is an upcoming modality of treatment, and we decided to study its efficacy by subcutaneous route. Aims: To evaluate the effectiveness of subcutaneous autologous serum therapy (AST) in CSU. Methods: This was a single blind, placebo-controlled parallel group, randomized, controlled study. Twenty-four patients with CSU (11M: 13 F) were given subcutaneous AST and seventeen patients (7 M: 10F) patients were given subcutaneous injection normal saline (placebo), along with levocetirizine in an on-demand basis in both groups. Results: Urticaria activity score (UAS) came down from 35.74 to 7 at the end of 9 weeks and the patients' requirement of antihistamines also reduced remarkably from 5.8 to 1.7 per week in the serum group. Sub-cutaneous saline group did not show statistically significant fall in UAS. Saline group showed UAS 32.8 at zero week to 22.1 at the end of 9 weeks. DLQI showed significant fall in serum group, from 14.26 to 4 at the end of 9 weeks. Conclusion: Subcutaneous autoserum therapy is effective in treatment of CSU.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2017;volume=62;issue=5;spage=505;epage=507;aulast=GodseAutologous serum therapychronic urticariasubcutaneous |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kiran Vasant Godse Nitin Nadkarni Sharmila Patil Aayushi Mehta |
spellingShingle |
Kiran Vasant Godse Nitin Nadkarni Sharmila Patil Aayushi Mehta Subcutaneous autologous serum therapy in chronic spontaneous urticaria Indian Journal of Dermatology Autologous serum therapy chronic urticaria subcutaneous |
author_facet |
Kiran Vasant Godse Nitin Nadkarni Sharmila Patil Aayushi Mehta |
author_sort |
Kiran Vasant Godse |
title |
Subcutaneous autologous serum therapy in chronic spontaneous urticaria |
title_short |
Subcutaneous autologous serum therapy in chronic spontaneous urticaria |
title_full |
Subcutaneous autologous serum therapy in chronic spontaneous urticaria |
title_fullStr |
Subcutaneous autologous serum therapy in chronic spontaneous urticaria |
title_full_unstemmed |
Subcutaneous autologous serum therapy in chronic spontaneous urticaria |
title_sort |
subcutaneous autologous serum therapy in chronic spontaneous urticaria |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Dermatology |
issn |
0019-5154 1998-3611 |
publishDate |
2017-01-01 |
description |
Background: There is a felt need for trying newer therapeutic modalities in patients with chronic spontaneous urticaria, especially in the subset of patients classified as non-responders to antihistamines. Autologous serum therapy is an upcoming modality of treatment, and we decided to study its efficacy by subcutaneous route. Aims: To evaluate the effectiveness of subcutaneous autologous serum therapy (AST) in CSU. Methods: This was a single blind, placebo-controlled parallel group, randomized, controlled study. Twenty-four patients with CSU (11M: 13 F) were given subcutaneous AST and seventeen patients (7 M: 10F) patients were given subcutaneous injection normal saline (placebo), along with levocetirizine in an on-demand basis in both groups. Results: Urticaria activity score (UAS) came down from 35.74 to 7 at the end of 9 weeks and the patients' requirement of antihistamines also reduced remarkably from 5.8 to 1.7 per week in the serum group. Sub-cutaneous saline group did not show statistically significant fall in UAS. Saline group showed UAS 32.8 at zero week to 22.1 at the end of 9 weeks. DLQI showed significant fall in serum group, from 14.26 to 4 at the end of 9 weeks.
Conclusion: Subcutaneous autoserum therapy is effective in treatment of CSU. |
topic |
Autologous serum therapy chronic urticaria subcutaneous |
url |
http://www.e-ijd.org/article.asp?issn=0019-5154;year=2017;volume=62;issue=5;spage=505;epage=507;aulast=Godse |
work_keys_str_mv |
AT kiranvasantgodse subcutaneousautologousserumtherapyinchronicspontaneousurticaria AT nitinnadkarni subcutaneousautologousserumtherapyinchronicspontaneousurticaria AT sharmilapatil subcutaneousautologousserumtherapyinchronicspontaneousurticaria AT aayushimehta subcutaneousautologousserumtherapyinchronicspontaneousurticaria |
_version_ |
1725192577170276352 |