Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling

Abstract Background Cancer-associated fibroblasts (CAFs), activated by tumour cells, are the predominant type of stromal cells in cancer tissue and play an important role in interacting with neoplastic cells to promote cancer progression. Epithelial-mesenchymal transition (EMT) is a key feature of m...

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Bibliographic Details
Main Authors: Cassandra Ringuette Goulet, Audrey Champagne, Geneviève Bernard, Dominique Vandal, Stéphane Chabaud, Frédéric Pouliot, Stéphane Bolduc
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Cancer
Subjects:
CAFs
IL-6
EMT
Bladder cancer
Online Access:http://link.springer.com/article/10.1186/s12885-019-5353-6

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