Therapeutic Approaches With Immune Checkpoint Inhibitors in Head and Neck Cancers and the Role of PD-L1 as a Biomarker
Head and neck squamous cell carcinoma (HNSCC) is a potential curative disease at its localized stage, by the use of multimodal treatment including surgery, radiation, and chemotherapy. While the metastatic stage is considered incurable and is characterized by poor prognosis. Conventional cytotoxic c...
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doaj-328565ab4e884cfe8e46789f70feae092021-04-09T00:34:54ZengSAGE PublishingCancer Control1073-27482021-04-012810.1177/10732748211004878Therapeutic Approaches With Immune Checkpoint Inhibitors in Head and Neck Cancers and the Role of PD-L1 as a BiomarkerKarima Oualla MD0Luis Castelo Branco MD1Lamiae Nouiyakh MD2Lamiae Amaadour MD3Zineb Benbrahim MD4Samia Arifi MD5Nawfel Mellas MD6 Medical Oncology Department, , University Sidi Mohamed Ben Abdellah, Fes, Morocco Clinical Oncology Algarve Medical and University Centre Faro, Faro, Portugal Medical Oncology Department, , University Sidi Mohamed Ben Abdellah, Fes, Morocco Medical Oncology Department, , University Sidi Mohamed Ben Abdellah, Fes, Morocco Medical Oncology Department, , University Sidi Mohamed Ben Abdellah, Fes, Morocco Medical Oncology Department, , University Sidi Mohamed Ben Abdellah, Fes, Morocco Medical Oncology Department, , University Sidi Mohamed Ben Abdellah, Fes, MoroccoHead and neck squamous cell carcinoma (HNSCC) is a potential curative disease at its localized stage, by the use of multimodal treatment including surgery, radiation, and chemotherapy. While the metastatic stage is considered incurable and is characterized by poor prognosis. Conventional cytotoxic chemotherapy in addition to cetuximab were the only available systemic treatment with limited efficacy and modest median overall survival barely crossing the 1 year limit. Immunotherapy with PD-1 and PD-L1 inhibitors has revolutionized the treatment of multiple cancers. Recently, Immunotherapy is being extensively explored in head and neck cancer and clinical trials have shown impressive results that allowed to immune check point inhibitors to be the new standard of care. In this article we tried to explain the rationale and mechanisms of targeting the immune system in head and neck carcinoma and to report the results from the phase III clinical trials that put the immunotherapy as a new standard of care for head and neck cancer.https://doi.org/10.1177/10732748211004878 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karima Oualla MD Luis Castelo Branco MD Lamiae Nouiyakh MD Lamiae Amaadour MD Zineb Benbrahim MD Samia Arifi MD Nawfel Mellas MD |
spellingShingle |
Karima Oualla MD Luis Castelo Branco MD Lamiae Nouiyakh MD Lamiae Amaadour MD Zineb Benbrahim MD Samia Arifi MD Nawfel Mellas MD Therapeutic Approaches With Immune Checkpoint Inhibitors in Head and Neck Cancers and the Role of PD-L1 as a Biomarker Cancer Control |
author_facet |
Karima Oualla MD Luis Castelo Branco MD Lamiae Nouiyakh MD Lamiae Amaadour MD Zineb Benbrahim MD Samia Arifi MD Nawfel Mellas MD |
author_sort |
Karima Oualla MD |
title |
Therapeutic Approaches With Immune Checkpoint Inhibitors in Head and Neck Cancers and the Role of PD-L1 as a Biomarker |
title_short |
Therapeutic Approaches With Immune Checkpoint Inhibitors in Head and Neck Cancers and the Role of PD-L1 as a Biomarker |
title_full |
Therapeutic Approaches With Immune Checkpoint Inhibitors in Head and Neck Cancers and the Role of PD-L1 as a Biomarker |
title_fullStr |
Therapeutic Approaches With Immune Checkpoint Inhibitors in Head and Neck Cancers and the Role of PD-L1 as a Biomarker |
title_full_unstemmed |
Therapeutic Approaches With Immune Checkpoint Inhibitors in Head and Neck Cancers and the Role of PD-L1 as a Biomarker |
title_sort |
therapeutic approaches with immune checkpoint inhibitors in head and neck cancers and the role of pd-l1 as a biomarker |
publisher |
SAGE Publishing |
series |
Cancer Control |
issn |
1073-2748 |
publishDate |
2021-04-01 |
description |
Head and neck squamous cell carcinoma (HNSCC) is a potential curative disease at its localized stage, by the use of multimodal treatment including surgery, radiation, and chemotherapy. While the metastatic stage is considered incurable and is characterized by poor prognosis. Conventional cytotoxic chemotherapy in addition to cetuximab were the only available systemic treatment with limited efficacy and modest median overall survival barely crossing the 1 year limit. Immunotherapy with PD-1 and PD-L1 inhibitors has revolutionized the treatment of multiple cancers. Recently, Immunotherapy is being extensively explored in head and neck cancer and clinical trials have shown impressive results that allowed to immune check point inhibitors to be the new standard of care. In this article we tried to explain the rationale and mechanisms of targeting the immune system in head and neck carcinoma and to report the results from the phase III clinical trials that put the immunotherapy as a new standard of care for head and neck cancer. |
url |
https://doi.org/10.1177/10732748211004878 |
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