Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats
This study was undertaken to investigate the Crataegus extract (CE) eff ;ects on diabetes-induced memory deficit in passive avoidance learning (PAL), blood glucose, and lipid profile panel. Male Wistar rats were divided into five groups: Control (CTRL); Diabetic (DM); and Diabetic animals treated wit...
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doaj-329818e675e64ef7bf0866e7b1737a9f2020-11-25T01:32:36ZengElsevierIBRO Reports2451-83012019-12-0179096Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male ratsAmin Pirmoghani0Iraj Salehi1Shirin Moradkhani2Seyed Asaad Karimi3Sakineh Salehi4Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Student Research Committee, Hamadan University of Medical Sciences, Hamadan, IranNeurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, IranMedicinal Plants and Natural Products Research Center, Department of Pharmacognosy and Pharmaceutical Biotechnology, School of pharmacy, Hamadan University of Medical Sciences, Hamadan, IranNeurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Corresponding author at: Department of Neuroscience, School of Medicine, Hamadan University of Medical Sciences, Postal Code: 65178/518, Hamadan, Iran.Department of Physiology and Neurophysiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranThis study was undertaken to investigate the Crataegus extract (CE) eff ;ects on diabetes-induced memory deficit in passive avoidance learning (PAL), blood glucose, and lipid profile panel. Male Wistar rats were divided into five groups: Control (CTRL); Diabetic (DM); and Diabetic animals treated with three doses of CE (100, 300 and 1000 mg/kg) (DM + CE). Streptozotocin (STZ)-induced diabetic rats (50 mg/kg, ip) were orally administrated with CE once a day for 2 weeks. After 2 weeks, PAL task was used to evaluate the passive avoidance learning and memory. At the end of experiment, the level of plasma glucose, triglycerides (TG), cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were determined. Our results showed that the step-through latency (STLr) in diabetic animals was less than the control group (P = 0.0009). Crataegus (300 mg) increased STLr in diabetic animals (P = 0.0418). Diabetic animals spent more time in the dark compartment (TDC) (P = 0.0009). Crataegus (300 and 1000 mg) decreased TDC in diabetic animals (P = 0.0175). Crataegus (100 and 300 mg) decreased blood glucose in diabetic animals (P < 0.001). TG and Cholesterol concentration increased in diabetic animals in comparison with control (P < 0.05). CE (100 and 300 mg) reduced the cholesterol concentration in diabetic animals (P < 0.001). There was no significant difference in the case of LDL among the experimental groups (P > 0.05). CE (1000 mg) increased HDL in diabetic animals (P < 0.05). Our findings demonstrated that CE had the hypolipidemic and hypoglycemic effects and lead to memory improvement in STZ-induced diabetes. Keywords: Diabetes mellitus, Crataegus extract, Learning and memory, Lipid profile, Wistar ratshttp://www.sciencedirect.com/science/article/pii/S2451830119319302 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amin Pirmoghani Iraj Salehi Shirin Moradkhani Seyed Asaad Karimi Sakineh Salehi |
spellingShingle |
Amin Pirmoghani Iraj Salehi Shirin Moradkhani Seyed Asaad Karimi Sakineh Salehi Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats IBRO Reports |
author_facet |
Amin Pirmoghani Iraj Salehi Shirin Moradkhani Seyed Asaad Karimi Sakineh Salehi |
author_sort |
Amin Pirmoghani |
title |
Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats |
title_short |
Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats |
title_full |
Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats |
title_fullStr |
Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats |
title_full_unstemmed |
Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats |
title_sort |
effect of crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats |
publisher |
Elsevier |
series |
IBRO Reports |
issn |
2451-8301 |
publishDate |
2019-12-01 |
description |
This study was undertaken to investigate the Crataegus extract (CE) eff ;ects on diabetes-induced memory deficit in passive avoidance learning (PAL), blood glucose, and lipid profile panel. Male Wistar rats were divided into five groups: Control (CTRL); Diabetic (DM); and Diabetic animals treated with three doses of CE (100, 300 and 1000 mg/kg) (DM + CE). Streptozotocin (STZ)-induced diabetic rats (50 mg/kg, ip) were orally administrated with CE once a day for 2 weeks. After 2 weeks, PAL task was used to evaluate the passive avoidance learning and memory. At the end of experiment, the level of plasma glucose, triglycerides (TG), cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were determined. Our results showed that the step-through latency (STLr) in diabetic animals was less than the control group (P = 0.0009). Crataegus (300 mg) increased STLr in diabetic animals (P = 0.0418). Diabetic animals spent more time in the dark compartment (TDC) (P = 0.0009). Crataegus (300 and 1000 mg) decreased TDC in diabetic animals (P = 0.0175). Crataegus (100 and 300 mg) decreased blood glucose in diabetic animals (P < 0.001). TG and Cholesterol concentration increased in diabetic animals in comparison with control (P < 0.05). CE (100 and 300 mg) reduced the cholesterol concentration in diabetic animals (P < 0.001). There was no significant difference in the case of LDL among the experimental groups (P > 0.05). CE (1000 mg) increased HDL in diabetic animals (P < 0.05). Our findings demonstrated that CE had the hypolipidemic and hypoglycemic effects and lead to memory improvement in STZ-induced diabetes. Keywords: Diabetes mellitus, Crataegus extract, Learning and memory, Lipid profile, Wistar rats |
url |
http://www.sciencedirect.com/science/article/pii/S2451830119319302 |
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