Application of the Log k pair linearity rule and Proportionality rule to the RPP mobile phase scales estimation on cyano-silica column

• Main Authors: MILENKO B. CELAP, TOMISLAV J. JANJIC, GORDANA VUCKOVIC
• Format: Article
• Language: English
• Published: Serbian Chemical Society 2001-03-01
• Series: Journal of the Serbian Chemical Society
• Subjects: column chromatography; cyano-silica sorbent; Log k pair linearity rule; Proportionality rule; RPP scale
• Online Access: http://www.shd.org.yu/HtDocs/SHD/Vol66/No3/v66-no3-04.pdf

On the basis of literature-reported log k values, the Log k pair linearity rule and the Proportionality rule were found to be also valid in the case of cyano-silica sorbent, whenmethanol, acetonitrile or propane-2-olwere used as modifiers. The RPP scales, reflecting the solvent strength, are in good linear relationship with the experimentally determined log k values. Furthermore, in the case of methanol and acetonitrile, the linear dependence: log k = f (mol% of modifier) was also established. In the function obtained in a such way, the intercept and the slope exhibit an approximate linear dependence. Finally, in the case of methanol, the experimentally obtained log k values are in a satisfactory agreement with the values calculated by the above equation.