Complex Size and Surface Charge Determine Nucleic Acid Transfer by Fusogenic Liposomes

Complex Size and Surface Charge Determine Nucleic Acid Transfer by Fusogenic Liposomes

Highly efficient, biocompatible, and fast nucleic acid delivery methods are essential for biomedical applications and research. At present, two main strategies are used to this end. In non-viral transfection liposome- or polymer-based formulations are used to transfer cargo into cells via endocytosi...

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Bibliographic Details
Main Authors: Marco Hoffmann, Nils Hersch, Sven Gerlach, Georg Dreissen, Ronald Springer, Rudolf Merkel, Agnes Csiszár, Bernd Hoffmann
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
fusogenic liposomes
transfection
nucleic acid complexation
membrane fusion
Online Access:https://www.mdpi.com/1422-0067/21/6/2244

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