Neural activity temporal pattern dictates long-range propagation targets
Brain possesses a complex spatiotemporal architecture for efficient information processing and computing. However, it remains unknown how neural signal propagates to its intended targets brain-wide. Using optogenetics and functional MRI, we arbitrarily initiated various discrete neural activity puls...
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2021-07-01
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doaj-32b190fd598c41ba8a5da2d7eb6c1da12021-06-09T05:49:48ZengElsevierNeuroImage1095-95722021-07-01235118032Neural activity temporal pattern dictates long-range propagation targetsAlex T.L. Leong0Xunda Wang1Eddie C. Wong2Celia M. Dong3Ed X. Wu4Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR; Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SARLaboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR; Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SARLaboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR; Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SARLaboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR; Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SARLaboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR; Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR; Corresponding author at: Laboratory of Biomedical Imaging and Signal Processing, Department of Electrical and Electronic Engineering, and School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, ChinaBrain possesses a complex spatiotemporal architecture for efficient information processing and computing. However, it remains unknown how neural signal propagates to its intended targets brain-wide. Using optogenetics and functional MRI, we arbitrarily initiated various discrete neural activity pulse trains with different temporal patterns and revealed their distinct long-range propagation targets within the well-defined, topographically organized somatosensory thalamo-cortical circuit. We further observed that such neural activity propagation over long range could modulate brain-wide sensory functions. Electrophysiological analysis indicated that distinct propagation pathways arose from system level neural adaptation and facilitation in response to the neural activity temporal characteristics. Together, our findings provide fundamental insights into the long-range information transfer and processing. They directly support that temporal coding underpins the whole brain functional architecture in presence of the vast and relatively static anatomical architecture.http://www.sciencedirect.com/science/article/pii/S1053811921003098fMRINeural activity propagationOptogeneticThalamo-corticalNeural codeTemporal code |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alex T.L. Leong Xunda Wang Eddie C. Wong Celia M. Dong Ed X. Wu |
spellingShingle |
Alex T.L. Leong Xunda Wang Eddie C. Wong Celia M. Dong Ed X. Wu Neural activity temporal pattern dictates long-range propagation targets NeuroImage fMRI Neural activity propagation Optogenetic Thalamo-cortical Neural code Temporal code |
author_facet |
Alex T.L. Leong Xunda Wang Eddie C. Wong Celia M. Dong Ed X. Wu |
author_sort |
Alex T.L. Leong |
title |
Neural activity temporal pattern dictates long-range propagation targets |
title_short |
Neural activity temporal pattern dictates long-range propagation targets |
title_full |
Neural activity temporal pattern dictates long-range propagation targets |
title_fullStr |
Neural activity temporal pattern dictates long-range propagation targets |
title_full_unstemmed |
Neural activity temporal pattern dictates long-range propagation targets |
title_sort |
neural activity temporal pattern dictates long-range propagation targets |
publisher |
Elsevier |
series |
NeuroImage |
issn |
1095-9572 |
publishDate |
2021-07-01 |
description |
Brain possesses a complex spatiotemporal architecture for efficient information processing and computing. However, it remains unknown how neural signal propagates to its intended targets brain-wide. Using optogenetics and functional MRI, we arbitrarily initiated various discrete neural activity pulse trains with different temporal patterns and revealed their distinct long-range propagation targets within the well-defined, topographically organized somatosensory thalamo-cortical circuit. We further observed that such neural activity propagation over long range could modulate brain-wide sensory functions. Electrophysiological analysis indicated that distinct propagation pathways arose from system level neural adaptation and facilitation in response to the neural activity temporal characteristics. Together, our findings provide fundamental insights into the long-range information transfer and processing. They directly support that temporal coding underpins the whole brain functional architecture in presence of the vast and relatively static anatomical architecture. |
topic |
fMRI Neural activity propagation Optogenetic Thalamo-cortical Neural code Temporal code |
url |
http://www.sciencedirect.com/science/article/pii/S1053811921003098 |
work_keys_str_mv |
AT alextlleong neuralactivitytemporalpatterndictateslongrangepropagationtargets AT xundawang neuralactivitytemporalpatterndictateslongrangepropagationtargets AT eddiecwong neuralactivitytemporalpatterndictateslongrangepropagationtargets AT celiamdong neuralactivitytemporalpatterndictateslongrangepropagationtargets AT edxwu neuralactivitytemporalpatterndictateslongrangepropagationtargets |
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1721389142038806528 |