A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate
Recent research in neuroscience indicates the importance of tripartite synapses and gliotransmission mediated by astrocytes in neuronal system modulation. Although the astrocyte and neuronal network functions are interrelated, they are fundamentally different in their signaling patterns and, possibl...
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doaj-32b236d335734ae1b801d39f2d5c7c872020-11-25T01:41:52ZengFrontiers Media S.A.Frontiers in Computational Neuroscience1662-51882020-01-011310.3389/fncom.2019.00092480462A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing RateKerstin Lenk0Eero Satuvuori1Eero Satuvuori2Eero Satuvuori3Eero Satuvuori4Jules Lallouette5Jules Lallouette6Antonio Ladrón-de-Guevara7Hugues Berry8Hugues Berry9Jari A. K. Hyttinen10BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandBioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandInstitute for Complex Systems (ISC), National Research Council (CNR), Sesto Fiorentino, ItalyDepartment of Physics and Astronomy, University of Florence, Sesto Fiorentino, ItalyDepartment of Human Movement Sciences, MOVE Research Institute Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsINRIA, Villeurbanne, FranceLIRIS UMR5205, University of Lyon, Villeurbanne, FranceBioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandINRIA, Villeurbanne, FranceLIRIS UMR5205, University of Lyon, Villeurbanne, FranceBioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandRecent research in neuroscience indicates the importance of tripartite synapses and gliotransmission mediated by astrocytes in neuronal system modulation. Although the astrocyte and neuronal network functions are interrelated, they are fundamentally different in their signaling patterns and, possibly, the time scales at which they operate. However, the exact nature of gliotransmission and the effect of the tripartite synapse function at the network level are currently elusive. In this paper, we propose a computational model of interactions between an astrocyte network and a neuron network, starting from tripartite synapses and spanning to a joint network level. Our model focuses on a two-dimensional setup emulating a mixed in vitro neuron-astrocyte cell culture. The model depicts astrocyte-released gliotransmitters exerting opposing effects on the neurons: increasing the release probability of the presynaptic neuron while hyperpolarizing the post-synaptic one at a longer time scale. We simulated the joint networks with various levels of astrocyte contributions and neuronal activity levels. Our results indicate that astrocytes prolong the burst duration of neurons, while restricting hyperactivity. Thus, in our model, the effect of astrocytes is homeostatic; the firing rate of the network stabilizes to an intermediate level independently of neuronal base activity. Our computational model highlights the plausible roles of astrocytes in interconnected astrocytic and neuronal networks. Our simulations support recent findings in neurons and astrocytes in vivo and in vitro suggesting that astrocytic networks provide a modulatory role in the bursting of the neuronal network.https://www.frontiersin.org/article/10.3389/fncom.2019.00092/fullsimulationneuronastrocytenetworkcalcium signalinggliotransmission |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kerstin Lenk Eero Satuvuori Eero Satuvuori Eero Satuvuori Eero Satuvuori Jules Lallouette Jules Lallouette Antonio Ladrón-de-Guevara Hugues Berry Hugues Berry Jari A. K. Hyttinen |
spellingShingle |
Kerstin Lenk Eero Satuvuori Eero Satuvuori Eero Satuvuori Eero Satuvuori Jules Lallouette Jules Lallouette Antonio Ladrón-de-Guevara Hugues Berry Hugues Berry Jari A. K. Hyttinen A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate Frontiers in Computational Neuroscience simulation neuron astrocyte network calcium signaling gliotransmission |
author_facet |
Kerstin Lenk Eero Satuvuori Eero Satuvuori Eero Satuvuori Eero Satuvuori Jules Lallouette Jules Lallouette Antonio Ladrón-de-Guevara Hugues Berry Hugues Berry Jari A. K. Hyttinen |
author_sort |
Kerstin Lenk |
title |
A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate |
title_short |
A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate |
title_full |
A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate |
title_fullStr |
A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate |
title_full_unstemmed |
A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate |
title_sort |
computational model of interactions between neuronal and astrocytic networks: the role of astrocytes in the stability of the neuronal firing rate |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Computational Neuroscience |
issn |
1662-5188 |
publishDate |
2020-01-01 |
description |
Recent research in neuroscience indicates the importance of tripartite synapses and gliotransmission mediated by astrocytes in neuronal system modulation. Although the astrocyte and neuronal network functions are interrelated, they are fundamentally different in their signaling patterns and, possibly, the time scales at which they operate. However, the exact nature of gliotransmission and the effect of the tripartite synapse function at the network level are currently elusive. In this paper, we propose a computational model of interactions between an astrocyte network and a neuron network, starting from tripartite synapses and spanning to a joint network level. Our model focuses on a two-dimensional setup emulating a mixed in vitro neuron-astrocyte cell culture. The model depicts astrocyte-released gliotransmitters exerting opposing effects on the neurons: increasing the release probability of the presynaptic neuron while hyperpolarizing the post-synaptic one at a longer time scale. We simulated the joint networks with various levels of astrocyte contributions and neuronal activity levels. Our results indicate that astrocytes prolong the burst duration of neurons, while restricting hyperactivity. Thus, in our model, the effect of astrocytes is homeostatic; the firing rate of the network stabilizes to an intermediate level independently of neuronal base activity. Our computational model highlights the plausible roles of astrocytes in interconnected astrocytic and neuronal networks. Our simulations support recent findings in neurons and astrocytes in vivo and in vitro suggesting that astrocytic networks provide a modulatory role in the bursting of the neuronal network. |
topic |
simulation neuron astrocyte network calcium signaling gliotransmission |
url |
https://www.frontiersin.org/article/10.3389/fncom.2019.00092/full |
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