Expression and significance of IGF-1R and MMP-2 in renal cancer tissues

• Main Authors: Feng-Ting Chen, Jie-Xian Li, Yu-Feng Lin, Ge Zou
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-06-01
• Series: Journal of Hainan Medical University
• Subjects: Renal cancer; IGF-1R; MMP-2; Pathological characteristics; Correlation
• Online Access: http://www.hnykdxxb.com/PDF/201611/33.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To explore the expressions of insulin-like growth factor 1 receptor (IGF-1R) and matrix metallopteinase 2 (MMP-2) in the renal cancer tissues, and analyze their correlations with the clinical and pathological characteristics. Methods: The specimens of cancer tissues and tissues adjacent to cancer in patients with renal cancer who were admitted in the urology department from January, 2014 to January, 2015 for renal radical resection were collected. The two-step method immunohistochemistry was used to detect the expressions of IGF-1R and MMP-2, their relations with the clinical and pathological characteristics were analyzed, and their mutual correlations in the renal cancer tissues were further analyzed. Results: Both the positive expression rate of IGF-1R and MMP-2 in the renal cancer tissues was 100.00%, significantly higher than that in the tissues adjacent to cancer (37.93%, 27.59%, respectively) (P<0.01). Age (曒50 years old), tumor diameter size (曒4 cm), pathological type, pathological staging, Furhman grading, and lymphatic metastasis were closely associated with the high positive expressions of IGF-1R and MMP-2 (P<0.05). IGF-1R expression was positively correlated with MMP-2 (P<0.05). Conclusions: IGF-1R and MMP-2 are abnormally highly expressed in the renal cancer tissue, are closely associated with age, tumor size, pathological staging, pathological type, pathological grading, and lymphatic metastasis, and their expressions are positively correlated.