PET/CT Imaging in Mouse Models of Myocardial Ischemia
Different species have been used to reproduce myocardial infarction models but in the last years mice became the animals of choice for the analysis of several diseases, due to their short life cycle and the possibility of genetic manipulation. Many techniques are currently used for cardiovascular im...
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Series: | Journal of Biomedicine and Biotechnology |
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doaj-32ef31f5988e44868efaef43be0f37c12020-11-25T01:40:07ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512012-01-01201210.1155/2012/541872541872PET/CT Imaging in Mouse Models of Myocardial IschemiaSara Gargiulo0Adelaide Greco1Matteo Gramanzini2Maria Piera Petretta3Adele Ferro4Michele Larobina5Mariarosaria Panico6Arturo Brunetti7Alberto Cuocolo8Department of Biomorphological and Functional Sciences and Institute of Biostructures and Bioimages of National Council of Research, University of Naples Federico II, Naples, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Biomorphological and Functional Sciences and Institute of Biostructures and Bioimages of National Council of Research, University of Naples Federico II, Naples, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Biomorphological and Functional Sciences and Institute of Biostructures and Bioimages of National Council of Research, University of Naples Federico II, Naples, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Biomorphological and Functional Sciences and Institute of Biostructures and Bioimages of National Council of Research, University of Naples Federico II, Naples, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Biomorphological and Functional Sciences and Institute of Biostructures and Bioimages of National Council of Research, University of Naples Federico II, Naples, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Biomorphological and Functional Sciences and Institute of Biostructures and Bioimages of National Council of Research, University of Naples Federico II, Naples, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Biomorphological and Functional Sciences and Institute of Biostructures and Bioimages of National Council of Research, University of Naples Federico II, Naples, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Biomorphological and Functional Sciences and Institute of Biostructures and Bioimages of National Council of Research, University of Naples Federico II, Naples, Via S. Pansini 5, 80131 Naples, ItalyDepartment of Biomorphological and Functional Sciences and Institute of Biostructures and Bioimages of National Council of Research, University of Naples Federico II, Naples, Via S. Pansini 5, 80131 Naples, ItalyDifferent species have been used to reproduce myocardial infarction models but in the last years mice became the animals of choice for the analysis of several diseases, due to their short life cycle and the possibility of genetic manipulation. Many techniques are currently used for cardiovascular imaging in mice, including X-ray computed tomography (CT), high-resolution ultrasound, magnetic resonance imaging, and nuclear medicine procedures. Cardiac positron emission tomography (PET) allows to examine noninvasively, on a molecular level and with high sensitivity, regional changes in myocardial perfusion, metabolism, apoptosis, inflammation, and gene expression or to measure changes in anatomical and functional parameters in heart diseases. Currently hybrid PET/CT scanners for small laboratory animals are available, where CT adds high-resolution anatomical information. This paper reviews mouse models of myocardial infarction and discusses the applications of dedicated PET/CT systems technology, including animal preparation, anesthesia, radiotracers, and images postprocessing.http://dx.doi.org/10.1155/2012/541872 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sara Gargiulo Adelaide Greco Matteo Gramanzini Maria Piera Petretta Adele Ferro Michele Larobina Mariarosaria Panico Arturo Brunetti Alberto Cuocolo |
spellingShingle |
Sara Gargiulo Adelaide Greco Matteo Gramanzini Maria Piera Petretta Adele Ferro Michele Larobina Mariarosaria Panico Arturo Brunetti Alberto Cuocolo PET/CT Imaging in Mouse Models of Myocardial Ischemia Journal of Biomedicine and Biotechnology |
author_facet |
Sara Gargiulo Adelaide Greco Matteo Gramanzini Maria Piera Petretta Adele Ferro Michele Larobina Mariarosaria Panico Arturo Brunetti Alberto Cuocolo |
author_sort |
Sara Gargiulo |
title |
PET/CT Imaging in Mouse Models of Myocardial Ischemia |
title_short |
PET/CT Imaging in Mouse Models of Myocardial Ischemia |
title_full |
PET/CT Imaging in Mouse Models of Myocardial Ischemia |
title_fullStr |
PET/CT Imaging in Mouse Models of Myocardial Ischemia |
title_full_unstemmed |
PET/CT Imaging in Mouse Models of Myocardial Ischemia |
title_sort |
pet/ct imaging in mouse models of myocardial ischemia |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2012-01-01 |
description |
Different species have been used to reproduce myocardial infarction models but in the last years mice became the animals of choice for the analysis of several diseases, due to their short life cycle and the possibility of genetic manipulation. Many techniques are currently used for cardiovascular imaging in mice, including X-ray computed tomography (CT), high-resolution ultrasound, magnetic resonance imaging, and nuclear medicine procedures. Cardiac positron emission tomography (PET) allows to examine noninvasively, on a molecular level and with high sensitivity, regional changes in myocardial perfusion, metabolism, apoptosis, inflammation, and gene expression or to measure changes in anatomical and functional parameters in heart diseases. Currently hybrid PET/CT scanners for small laboratory animals are available, where CT adds high-resolution anatomical information. This paper reviews mouse models of myocardial infarction and discusses the applications of dedicated PET/CT systems technology, including animal preparation, anesthesia, radiotracers, and images postprocessing. |
url |
http://dx.doi.org/10.1155/2012/541872 |
work_keys_str_mv |
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1725047018959667200 |