Au nanostars@PDA@Fe3O4-based multifunctional nanoprobe for integrated tumor diagnosis and photothermal therapy
A multifunctional nanoprobe (based on Au nanostars@PDA@Fe3O4) is developed for tumor targeted imaging and targeted photothermal therapy. Au nanostars and Fe3O4 are connected with polydopamine, and combined with antibody-FITC or antibody-quantum dots for in vitro or in vivo fluorescence labeling (FL)...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-07-01
|
Series: | Materials & Design |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127521002598 |
id |
doaj-32f2e698b37240aab1abc818d54fba4e |
---|---|
record_format |
Article |
spelling |
doaj-32f2e698b37240aab1abc818d54fba4e2021-06-11T05:11:22ZengElsevierMaterials & Design0264-12752021-07-01205109707Au nanostars@PDA@Fe3O4-based multifunctional nanoprobe for integrated tumor diagnosis and photothermal therapyShuhui Wang0Yan Zhang1Yuanjin Li2Kui Chen3Yiwen Dai4Dachen Zhou5Asad Ali6Siyu Yang7Xiaoliang Xu8Tongtong Jiang9Lixin Zhu10Key Laboratory of Strongly-Coupled Quantum Matter Physics, School of Physics, University of Science and Technology of China, Hefei, Anhui 230026, PR ChinaDepartment of General Surgery & Central Laboratory, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, PR ChinaKey Laboratory of Strongly-Coupled Quantum Matter Physics, School of Physics, University of Science and Technology of China, Hefei, Anhui 230026, PR ChinaKey Laboratory of Strongly-Coupled Quantum Matter Physics, School of Physics, University of Science and Technology of China, Hefei, Anhui 230026, PR ChinaDepartment of General Surgery, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230000, PR ChinaDepartment of General Surgery, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230000, PR ChinaKey Laboratory of Strongly-Coupled Quantum Matter Physics, School of Physics, University of Science and Technology of China, Hefei, Anhui 230026, PR ChinaKey Laboratory of Strongly-Coupled Quantum Matter Physics, School of Physics, University of Science and Technology of China, Hefei, Anhui 230026, PR ChinaKey Laboratory of Strongly-Coupled Quantum Matter Physics, School of Physics, University of Science and Technology of China, Hefei, Anhui 230026, PR China; Corresponding authors.School of Physics and Materials Science, Anhui University, Hefei, Anhui 230601, PR China; Corresponding authors.Department of General Surgery & Central Laboratory, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, PR China; Corresponding authors.A multifunctional nanoprobe (based on Au nanostars@PDA@Fe3O4) is developed for tumor targeted imaging and targeted photothermal therapy. Au nanostars and Fe3O4 are connected with polydopamine, and combined with antibody-FITC or antibody-quantum dots for in vitro or in vivo fluorescence labeling (FL), respectively, to form the composite nanoprobe. The shape and lattice structure of Au nanostars and Fe3O4 were confirmed with TEM, HRTEM and XRD experiments. Compared with other Au nanoparticles@Fe3O4 composite probes, the Au nanostars@PDA@Fe3O4 structure has a low photothermal conversion threshold. Compared with the corresponding pure Au nanostars, the photothermal efficiency of the probe has increased by 50%, while maintaining 171% and 32% fluorescence enhancement in vitro and in vivo, respectively. Due to the charge transfer channel, the phonon emission of Au can go on in Fe3O4 via the PDA linking. Under the precise guidance of multimodal imaging, the nanoprobe conducts homogeneous photothermal ablation of bulky solid tumors (~ 400 mm3) in a xenograft mouse model. Animal model magnetic resonance imaging (MRI) results found that the MRI T2 signal intensity of the probe was 65% stronger than that of pure Fe3O4 nanoparticles. These results suggest that this nanoplatform is promising for integrated tumor diagnosis and targeted cancer therapy.http://www.sciencedirect.com/science/article/pii/S0264127521002598SuperparamagnetismPhotothermal therapyTargetingComposite nanoprobeMultifunctional nanoprobe |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shuhui Wang Yan Zhang Yuanjin Li Kui Chen Yiwen Dai Dachen Zhou Asad Ali Siyu Yang Xiaoliang Xu Tongtong Jiang Lixin Zhu |
spellingShingle |
Shuhui Wang Yan Zhang Yuanjin Li Kui Chen Yiwen Dai Dachen Zhou Asad Ali Siyu Yang Xiaoliang Xu Tongtong Jiang Lixin Zhu Au nanostars@PDA@Fe3O4-based multifunctional nanoprobe for integrated tumor diagnosis and photothermal therapy Materials & Design Superparamagnetism Photothermal therapy Targeting Composite nanoprobe Multifunctional nanoprobe |
author_facet |
Shuhui Wang Yan Zhang Yuanjin Li Kui Chen Yiwen Dai Dachen Zhou Asad Ali Siyu Yang Xiaoliang Xu Tongtong Jiang Lixin Zhu |
author_sort |
Shuhui Wang |
title |
Au nanostars@PDA@Fe3O4-based multifunctional nanoprobe for integrated tumor diagnosis and photothermal therapy |
title_short |
Au nanostars@PDA@Fe3O4-based multifunctional nanoprobe for integrated tumor diagnosis and photothermal therapy |
title_full |
Au nanostars@PDA@Fe3O4-based multifunctional nanoprobe for integrated tumor diagnosis and photothermal therapy |
title_fullStr |
Au nanostars@PDA@Fe3O4-based multifunctional nanoprobe for integrated tumor diagnosis and photothermal therapy |
title_full_unstemmed |
Au nanostars@PDA@Fe3O4-based multifunctional nanoprobe for integrated tumor diagnosis and photothermal therapy |
title_sort |
au nanostars@pda@fe3o4-based multifunctional nanoprobe for integrated tumor diagnosis and photothermal therapy |
publisher |
Elsevier |
series |
Materials & Design |
issn |
0264-1275 |
publishDate |
2021-07-01 |
description |
A multifunctional nanoprobe (based on Au nanostars@PDA@Fe3O4) is developed for tumor targeted imaging and targeted photothermal therapy. Au nanostars and Fe3O4 are connected with polydopamine, and combined with antibody-FITC or antibody-quantum dots for in vitro or in vivo fluorescence labeling (FL), respectively, to form the composite nanoprobe. The shape and lattice structure of Au nanostars and Fe3O4 were confirmed with TEM, HRTEM and XRD experiments. Compared with other Au nanoparticles@Fe3O4 composite probes, the Au nanostars@PDA@Fe3O4 structure has a low photothermal conversion threshold. Compared with the corresponding pure Au nanostars, the photothermal efficiency of the probe has increased by 50%, while maintaining 171% and 32% fluorescence enhancement in vitro and in vivo, respectively. Due to the charge transfer channel, the phonon emission of Au can go on in Fe3O4 via the PDA linking. Under the precise guidance of multimodal imaging, the nanoprobe conducts homogeneous photothermal ablation of bulky solid tumors (~ 400 mm3) in a xenograft mouse model. Animal model magnetic resonance imaging (MRI) results found that the MRI T2 signal intensity of the probe was 65% stronger than that of pure Fe3O4 nanoparticles. These results suggest that this nanoplatform is promising for integrated tumor diagnosis and targeted cancer therapy. |
topic |
Superparamagnetism Photothermal therapy Targeting Composite nanoprobe Multifunctional nanoprobe |
url |
http://www.sciencedirect.com/science/article/pii/S0264127521002598 |
work_keys_str_mv |
AT shuhuiwang aunanostarspdafe3o4basedmultifunctionalnanoprobeforintegratedtumordiagnosisandphotothermaltherapy AT yanzhang aunanostarspdafe3o4basedmultifunctionalnanoprobeforintegratedtumordiagnosisandphotothermaltherapy AT yuanjinli aunanostarspdafe3o4basedmultifunctionalnanoprobeforintegratedtumordiagnosisandphotothermaltherapy AT kuichen aunanostarspdafe3o4basedmultifunctionalnanoprobeforintegratedtumordiagnosisandphotothermaltherapy AT yiwendai aunanostarspdafe3o4basedmultifunctionalnanoprobeforintegratedtumordiagnosisandphotothermaltherapy AT dachenzhou aunanostarspdafe3o4basedmultifunctionalnanoprobeforintegratedtumordiagnosisandphotothermaltherapy AT asadali aunanostarspdafe3o4basedmultifunctionalnanoprobeforintegratedtumordiagnosisandphotothermaltherapy AT siyuyang aunanostarspdafe3o4basedmultifunctionalnanoprobeforintegratedtumordiagnosisandphotothermaltherapy AT xiaoliangxu aunanostarspdafe3o4basedmultifunctionalnanoprobeforintegratedtumordiagnosisandphotothermaltherapy AT tongtongjiang aunanostarspdafe3o4basedmultifunctionalnanoprobeforintegratedtumordiagnosisandphotothermaltherapy AT lixinzhu aunanostarspdafe3o4basedmultifunctionalnanoprobeforintegratedtumordiagnosisandphotothermaltherapy |
_version_ |
1721383684975624192 |