Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-specific Clinical and Genetic Markers
Paradoxical psoriasis (PP) may occur during treatment with anti-tumor necrosis factor-alpha (TNF-α) drugs in various chronic immune-mediated diseases, mainly inflammatory bowel diseases (IBD) and psoriasis. In this study, clinical and genetic characteristics of PP arising in IBD and psoriatic patien...
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doaj-32f3027db814402da0535e67ceed4cac2020-11-25T03:37:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-01217873787310.3390/ijms21217873Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-specific Clinical and Genetic MarkersAgostino Bucalo0Federica Rega1Arianna Zangrilli2Valentina Silvestri3Virginia Valentini4Giorgia Scafetta5Federica Marraffa6Sara Grassi7Elena Rogante8Arianna Piccolo9Salvatore Cucchiara10Franca Viola11Luca Bianchi12Laura Ottini13Antonio Richetta14Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyClinic of Dermatology Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyDermatology Unit, Policlinico Tor Vergata, Tor Vergata University of Rome, 00133 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyClinic of Dermatology Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyClinic of Dermatology Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyClinic of Dermatology Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyDermatology Unit, Policlinico Tor Vergata, Tor Vergata University of Rome, 00133 Rome, ItalyPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, 00161 Rome, ItalyPediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, 00161 Rome, ItalyDermatology Unit, Policlinico Tor Vergata, Tor Vergata University of Rome, 00133 Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, ItalyClinic of Dermatology Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyParadoxical psoriasis (PP) may occur during treatment with anti-tumor necrosis factor-alpha (TNF-α) drugs in various chronic immune-mediated diseases, mainly inflammatory bowel diseases (IBD) and psoriasis. In this study, clinical and genetic characteristics of PP arising in IBD and psoriatic patients were investigated to identify disease-specific markers of the paradoxical effect. A total of 161 IBD and psoriatic patients treated with anti-TNF-α drugs were included in the study. Of these patients, 39 developed PP. All patients were characterized for the main clinical–pathologic characteristics and genotyped for six candidate single nucleotide polymorphisms (SNPs) selected for their possible role in PP susceptibility. In IBD patients, the onset of PP was associated with female sex, presence of comorbidities, and use of adalimumab. IBD patients with PP had a higher frequency of the <i>TNF-α </i>rs1799964 rare allele (<i>p</i>= 0.006) compared with cases without the paradoxical effect, and a lower frequency of the human leucocyte antigen (<i>HLA)-Cw06 </i>rs10484554 rare allele (<i>p</i>= 0.03) compared with psoriatic patients with PP. Overall, these findings point to specific clinical and genetic characteristics of IBD patients with PP and provide data showing that genetic variability may be related to the paradoxical effect of anti-TNF-α drugs with possible implications into clinical practice.https://www.mdpi.com/1422-0067/21/21/7873Paradoxical PsoriasisInflammatory Bowel DiseasePsoriasisTumor necrosis factor-alpha inhibitorsGenetic Polymorphisms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Agostino Bucalo Federica Rega Arianna Zangrilli Valentina Silvestri Virginia Valentini Giorgia Scafetta Federica Marraffa Sara Grassi Elena Rogante Arianna Piccolo Salvatore Cucchiara Franca Viola Luca Bianchi Laura Ottini Antonio Richetta |
spellingShingle |
Agostino Bucalo Federica Rega Arianna Zangrilli Valentina Silvestri Virginia Valentini Giorgia Scafetta Federica Marraffa Sara Grassi Elena Rogante Arianna Piccolo Salvatore Cucchiara Franca Viola Luca Bianchi Laura Ottini Antonio Richetta Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-specific Clinical and Genetic Markers International Journal of Molecular Sciences Paradoxical Psoriasis Inflammatory Bowel Disease Psoriasis Tumor necrosis factor-alpha inhibitors Genetic Polymorphisms |
author_facet |
Agostino Bucalo Federica Rega Arianna Zangrilli Valentina Silvestri Virginia Valentini Giorgia Scafetta Federica Marraffa Sara Grassi Elena Rogante Arianna Piccolo Salvatore Cucchiara Franca Viola Luca Bianchi Laura Ottini Antonio Richetta |
author_sort |
Agostino Bucalo |
title |
Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-specific Clinical and Genetic Markers |
title_short |
Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-specific Clinical and Genetic Markers |
title_full |
Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-specific Clinical and Genetic Markers |
title_fullStr |
Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-specific Clinical and Genetic Markers |
title_full_unstemmed |
Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-specific Clinical and Genetic Markers |
title_sort |
paradoxical psoriasis induced by anti-tnfα treatment: evaluation of disease-specific clinical and genetic markers |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-10-01 |
description |
Paradoxical psoriasis (PP) may occur during treatment with anti-tumor necrosis factor-alpha (TNF-α) drugs in various chronic immune-mediated diseases, mainly inflammatory bowel diseases (IBD) and psoriasis. In this study, clinical and genetic characteristics of PP arising in IBD and psoriatic patients were investigated to identify disease-specific markers of the paradoxical effect. A total of 161 IBD and psoriatic patients treated with anti-TNF-α drugs were included in the study. Of these patients, 39 developed PP. All patients were characterized for the main clinical–pathologic characteristics and genotyped for six candidate single nucleotide polymorphisms (SNPs) selected for their possible role in PP susceptibility. In IBD patients, the onset of PP was associated with female sex, presence of comorbidities, and use of adalimumab. IBD patients with PP had a higher frequency of the <i>TNF-α </i>rs1799964 rare allele (<i>p</i>= 0.006) compared with cases without the paradoxical effect, and a lower frequency of the human leucocyte antigen (<i>HLA)-Cw06 </i>rs10484554 rare allele (<i>p</i>= 0.03) compared with psoriatic patients with PP. Overall, these findings point to specific clinical and genetic characteristics of IBD patients with PP and provide data showing that genetic variability may be related to the paradoxical effect of anti-TNF-α drugs with possible implications into clinical practice. |
topic |
Paradoxical Psoriasis Inflammatory Bowel Disease Psoriasis Tumor necrosis factor-alpha inhibitors Genetic Polymorphisms |
url |
https://www.mdpi.com/1422-0067/21/21/7873 |
work_keys_str_mv |
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