Tumor cell phenotype is sustained by selective MAPK oxidation in mitochondria.
Mitochondria are major cellular sources of hydrogen peroxide (H(2)O(2)), the production of which is modulated by oxygen availability and the mitochondrial energy state. An increase of steady-state cell H(2)O(2) concentration is able to control the transition from proliferating to quiescent phenotype...
Main Authors: | Soledad Galli, Valeria Gabriela Antico Arciuch, Cecilia Poderoso, Daniela Paola Converso, Qiongqiong Zhou, Elisa Bal de Kier Joffé, Enrique Cadenas, Jorge Boczkowski, María Cecilia Carreras, Juan José Poderoso |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-06-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2398776?pdf=render |
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