Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic Cancer
Pancreatic cancer (PC) is the utmost stroma-rich cancer, which is accompanied by fibrotic reactions that stimulate interactions between tumor cells and stroma to promote tumor progression. Considerable research evidence denotes that insulin-like growth factor (IGF)/IGF binding proteins (IGFBP) signa...
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doaj-32ff895e285443e9aa7c808beb0f2e0d2020-11-25T03:47:20ZengMDPI AGCancers2072-66942020-05-01121228122810.3390/cancers12051228Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic CancerDivya Thomas0Prakash Radhakrishnan1Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-6805, USAEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-6805, USAPancreatic cancer (PC) is the utmost stroma-rich cancer, which is accompanied by fibrotic reactions that stimulate interactions between tumor cells and stroma to promote tumor progression. Considerable research evidence denotes that insulin-like growth factor (IGF)/IGF binding proteins (IGFBP) signaling axis facilitate tumor growth, metastasis, drug resistance, and thereby facilitate PC into an advanced stage. The six members of IGFBPs were initially considered as passive carriers of free IGFs; however, current evidence revealed their functions beyond the endocrine role in IGF transport. Though numerous efforts have been made in blocking IGF/IGFBPs, the targeted therapies remain unsuccessful due to the complexity of tumor-stromal interactions in the pancreas. In this review, we explore the emerging evidence of the various roles of the tumor as well as stroma derived IGF/IGFBPs and highlight as a novel therapeutic target against PC progression.https://www.mdpi.com/2072-6694/12/5/1228insulin-like growth factor signalinginsulin-like growth factor binding proteinspancreatic cancerextracellular matrixtumor microenvironment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Divya Thomas Prakash Radhakrishnan |
spellingShingle |
Divya Thomas Prakash Radhakrishnan Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic Cancer Cancers insulin-like growth factor signaling insulin-like growth factor binding proteins pancreatic cancer extracellular matrix tumor microenvironment |
author_facet |
Divya Thomas Prakash Radhakrishnan |
author_sort |
Divya Thomas |
title |
Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic Cancer |
title_short |
Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic Cancer |
title_full |
Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic Cancer |
title_fullStr |
Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic Cancer |
title_full_unstemmed |
Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic Cancer |
title_sort |
role of tumor and stroma-derived igf/igfbps in pancreatic cancer |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-05-01 |
description |
Pancreatic cancer (PC) is the utmost stroma-rich cancer, which is accompanied by fibrotic reactions that stimulate interactions between tumor cells and stroma to promote tumor progression. Considerable research evidence denotes that insulin-like growth factor (IGF)/IGF binding proteins (IGFBP) signaling axis facilitate tumor growth, metastasis, drug resistance, and thereby facilitate PC into an advanced stage. The six members of IGFBPs were initially considered as passive carriers of free IGFs; however, current evidence revealed their functions beyond the endocrine role in IGF transport. Though numerous efforts have been made in blocking IGF/IGFBPs, the targeted therapies remain unsuccessful due to the complexity of tumor-stromal interactions in the pancreas. In this review, we explore the emerging evidence of the various roles of the tumor as well as stroma derived IGF/IGFBPs and highlight as a novel therapeutic target against PC progression. |
topic |
insulin-like growth factor signaling insulin-like growth factor binding proteins pancreatic cancer extracellular matrix tumor microenvironment |
url |
https://www.mdpi.com/2072-6694/12/5/1228 |
work_keys_str_mv |
AT divyathomas roleoftumorandstromaderivedigfigfbpsinpancreaticcancer AT prakashradhakrishnan roleoftumorandstromaderivedigfigfbpsinpancreaticcancer |
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