Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias
Abstract Background Non-verbal auditory impairment is increasingly recognised in the primary progressive aphasias (PPAs) but its relationship to speech processing and brain substrates has not been defined. Here we addressed these issues in patients representing the non-fluent variant (nfvPPA) and se...
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doaj-330088e3d5074a669c1e7fb5c727e7ce2020-11-25T02:16:44ZengBMCAlzheimer’s Research & Therapy1758-91932017-07-019111010.1186/s13195-017-0278-2Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasiasChris J. D. Hardy0Jennifer L. Agustus1Charles R. Marshall2Camilla N. Clark3Lucy L. Russell4Rebecca L. Bond5Emilie V. Brotherhood6David L. Thomas7Sebastian J. Crutch8Jonathan D. Rohrer9Jason D. Warren10Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College LondonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College LondonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College LondonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College LondonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College LondonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College LondonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College LondonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College LondonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College LondonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College LondonDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, University College LondonAbstract Background Non-verbal auditory impairment is increasingly recognised in the primary progressive aphasias (PPAs) but its relationship to speech processing and brain substrates has not been defined. Here we addressed these issues in patients representing the non-fluent variant (nfvPPA) and semantic variant (svPPA) syndromes of PPA. Methods We studied 19 patients with PPA in relation to 19 healthy older individuals. We manipulated three key auditory parameters—temporal regularity, phonemic spectral structure and prosodic predictability (an index of fundamental information content, or entropy)—in sequences of spoken syllables. The ability of participants to process these parameters was assessed using two-alternative, forced-choice tasks and neuroanatomical associations of task performance were assessed using voxel-based morphometry of patients’ brain magnetic resonance images. Results Relative to healthy controls, both the nfvPPA and svPPA groups had impaired processing of phonemic spectral structure and signal predictability while the nfvPPA group additionally had impaired processing of temporal regularity in speech signals. Task performance correlated with standard disease severity and neurolinguistic measures. Across the patient cohort, performance on the temporal regularity task was associated with grey matter in the left supplementary motor area and right caudate, performance on the phoneme processing task was associated with grey matter in the left supramarginal gyrus, and performance on the prosodic predictability task was associated with grey matter in the right putamen. Conclusions Our findings suggest that PPA syndromes may be underpinned by more generic deficits of auditory signal analysis, with a distributed cortico-subcortical neuraoanatomical substrate extending beyond the canonical language network. This has implications for syndrome classification and biomarker development.http://link.springer.com/article/10.1186/s13195-017-0278-2SpeechAuditoryVoxel-based morphometryPrimary progressive aphasiaSemantic dementiaProgressive non-fluent aphasia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chris J. D. Hardy Jennifer L. Agustus Charles R. Marshall Camilla N. Clark Lucy L. Russell Rebecca L. Bond Emilie V. Brotherhood David L. Thomas Sebastian J. Crutch Jonathan D. Rohrer Jason D. Warren |
spellingShingle |
Chris J. D. Hardy Jennifer L. Agustus Charles R. Marshall Camilla N. Clark Lucy L. Russell Rebecca L. Bond Emilie V. Brotherhood David L. Thomas Sebastian J. Crutch Jonathan D. Rohrer Jason D. Warren Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias Alzheimer’s Research & Therapy Speech Auditory Voxel-based morphometry Primary progressive aphasia Semantic dementia Progressive non-fluent aphasia |
author_facet |
Chris J. D. Hardy Jennifer L. Agustus Charles R. Marshall Camilla N. Clark Lucy L. Russell Rebecca L. Bond Emilie V. Brotherhood David L. Thomas Sebastian J. Crutch Jonathan D. Rohrer Jason D. Warren |
author_sort |
Chris J. D. Hardy |
title |
Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias |
title_short |
Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias |
title_full |
Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias |
title_fullStr |
Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias |
title_full_unstemmed |
Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias |
title_sort |
behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias |
publisher |
BMC |
series |
Alzheimer’s Research & Therapy |
issn |
1758-9193 |
publishDate |
2017-07-01 |
description |
Abstract Background Non-verbal auditory impairment is increasingly recognised in the primary progressive aphasias (PPAs) but its relationship to speech processing and brain substrates has not been defined. Here we addressed these issues in patients representing the non-fluent variant (nfvPPA) and semantic variant (svPPA) syndromes of PPA. Methods We studied 19 patients with PPA in relation to 19 healthy older individuals. We manipulated three key auditory parameters—temporal regularity, phonemic spectral structure and prosodic predictability (an index of fundamental information content, or entropy)—in sequences of spoken syllables. The ability of participants to process these parameters was assessed using two-alternative, forced-choice tasks and neuroanatomical associations of task performance were assessed using voxel-based morphometry of patients’ brain magnetic resonance images. Results Relative to healthy controls, both the nfvPPA and svPPA groups had impaired processing of phonemic spectral structure and signal predictability while the nfvPPA group additionally had impaired processing of temporal regularity in speech signals. Task performance correlated with standard disease severity and neurolinguistic measures. Across the patient cohort, performance on the temporal regularity task was associated with grey matter in the left supplementary motor area and right caudate, performance on the phoneme processing task was associated with grey matter in the left supramarginal gyrus, and performance on the prosodic predictability task was associated with grey matter in the right putamen. Conclusions Our findings suggest that PPA syndromes may be underpinned by more generic deficits of auditory signal analysis, with a distributed cortico-subcortical neuraoanatomical substrate extending beyond the canonical language network. This has implications for syndrome classification and biomarker development. |
topic |
Speech Auditory Voxel-based morphometry Primary progressive aphasia Semantic dementia Progressive non-fluent aphasia |
url |
http://link.springer.com/article/10.1186/s13195-017-0278-2 |
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