| Summary: | Background: Breast cancer in very young women (BCVY) defined as <35 years old, presents with different molecular biology than in older patients. High <i>HDAC5</i> expression has been associated with poor prognosis in breast cancer (BC) tissue. We aimed to analyze <i>HDAC5</i> expression in BCVY and older patients and their correlation with clinical features, also studying the potential of HDAC5 inhibition in BC cell lines. Methods: <i>HDAC5</i> expression in 60 BCVY and 47 older cases were analyzed by qRT-PCR and correlated with clinical data. The effect of the HDAC5 inhibitor, LMK-235, was analyzed in BC cell lines from older and young patients. We performed time and dose dependence viability, migration, proliferation, and apoptosis assays. Results: Our results correlate higher <i>HDAC5</i> expression with worse prognosis in BCVY. However, we observed no differences between <i>HDAC5</i> expression and pathological features. Our results showed greatly reduced progression in BCVY cell lines and also in all triple negative subtypes when cell lines were treated with LMK-235. Conclusions: In BCVY, we found higher expression of <i>HDAC5</i>. Overexpression of <i>HDAC5</i> in BCVY correlates with lower survival rates. LMK-235 could be a potential treatment in BCVY.
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