The Role of FoxG1 in the Inner Ear
Sensorineural deafness is mainly caused by damage to the tissues of the inner ear, and hearing impairment has become an increasingly serious global health problem. When the inner ear is abnormally developed or is damaged by inflammation, ototoxic drugs, or blood supply disorders, auditory signal tra...
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2020-12-01
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doaj-330becc492434743b3d5d8bd3c3c943c2020-12-08T08:36:14ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-12-01810.3389/fcell.2020.614954614954The Role of FoxG1 in the Inner EarYanyan Ding0Wei Meng1Weijia Kong2Zuhong He3Renjie Chai4Renjie Chai5Renjie Chai6Renjie Chai7Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Otolaryngology Head and Neck, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, ChinaDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaState Key Laboratory of Bioelectronics, School of Life Sciences and Technology, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, ChinaCo-Innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaInstitute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, ChinaBeijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, Beijing, ChinaSensorineural deafness is mainly caused by damage to the tissues of the inner ear, and hearing impairment has become an increasingly serious global health problem. When the inner ear is abnormally developed or is damaged by inflammation, ototoxic drugs, or blood supply disorders, auditory signal transmission is inhibited resulting in hearing loss. Forkhead box G1 (FoxG1) is an important nuclear transcriptional regulator, which is related to the differentiation, proliferation, development, and survival of cells in the brain, telencephalon, inner ear, and other tissues. Previous studies have shown that when FoxG1 is abnormally expressed, the development and function of inner ear hair cells is impaired. This review discusses the role and regulatory mechanism of FoxG1 in inner ear tissue from various aspects – such as the effect on inner ear development, the maintenance of inner ear structure and function, and its role in the inner ear when subjected to various stimulations or injuries – in order to explain the potential significance of FoxG1 as a new target for the treatment of hearing loss.https://www.frontiersin.org/articles/10.3389/fcell.2020.614954/fullFoxG1hearing lossinner ear hair cellsautophagydevelopment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yanyan Ding Wei Meng Weijia Kong Zuhong He Renjie Chai Renjie Chai Renjie Chai Renjie Chai |
spellingShingle |
Yanyan Ding Wei Meng Weijia Kong Zuhong He Renjie Chai Renjie Chai Renjie Chai Renjie Chai The Role of FoxG1 in the Inner Ear Frontiers in Cell and Developmental Biology FoxG1 hearing loss inner ear hair cells autophagy development |
author_facet |
Yanyan Ding Wei Meng Weijia Kong Zuhong He Renjie Chai Renjie Chai Renjie Chai Renjie Chai |
author_sort |
Yanyan Ding |
title |
The Role of FoxG1 in the Inner Ear |
title_short |
The Role of FoxG1 in the Inner Ear |
title_full |
The Role of FoxG1 in the Inner Ear |
title_fullStr |
The Role of FoxG1 in the Inner Ear |
title_full_unstemmed |
The Role of FoxG1 in the Inner Ear |
title_sort |
role of foxg1 in the inner ear |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-12-01 |
description |
Sensorineural deafness is mainly caused by damage to the tissues of the inner ear, and hearing impairment has become an increasingly serious global health problem. When the inner ear is abnormally developed or is damaged by inflammation, ototoxic drugs, or blood supply disorders, auditory signal transmission is inhibited resulting in hearing loss. Forkhead box G1 (FoxG1) is an important nuclear transcriptional regulator, which is related to the differentiation, proliferation, development, and survival of cells in the brain, telencephalon, inner ear, and other tissues. Previous studies have shown that when FoxG1 is abnormally expressed, the development and function of inner ear hair cells is impaired. This review discusses the role and regulatory mechanism of FoxG1 in inner ear tissue from various aspects – such as the effect on inner ear development, the maintenance of inner ear structure and function, and its role in the inner ear when subjected to various stimulations or injuries – in order to explain the potential significance of FoxG1 as a new target for the treatment of hearing loss. |
topic |
FoxG1 hearing loss inner ear hair cells autophagy development |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2020.614954/full |
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