The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells

The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells

Colorectal cancer (CRC) is the third most common cancer in the United States. The exact mechanism of CRC cells metastasis is poorly understood. Actin polymerization is thought to be an initial step in the cancer cell motility cycle which drives the formation of cell protrusions and defines the direc...

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Main Authors: S M Anisul Islam, Rekha Patel, Raja Reddy Bommareddy, Khandker Mohammad Khalid, Mildred Acevedo-Duncan
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Cell Adhesion & Migration
Subjects:
crc
metastasis
actin dynamics
pkc-ι
pkc-ζ
cofilin
Online Access:http://dx.doi.org/10.1080/19336918.2018.1546513
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spelling doaj-330f01d3cd674f578a5fc26a3b7b03802020-11-25T01:30:23ZengTaylor & Francis GroupCell Adhesion & Migration1933-69181933-69262019-01-0113110612010.1080/19336918.2018.15465131546513The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cellsS M Anisul Islam0Rekha Patel1Raja Reddy Bommareddy2Khandker Mohammad Khalid3Mildred Acevedo-Duncan4University of South FloridaUniversity of South FloridaUniversity of South FloridaUniversity of South FloridaUniversity of South FloridaColorectal cancer (CRC) is the third most common cancer in the United States. The exact mechanism of CRC cells metastasis is poorly understood. Actin polymerization is thought to be an initial step in the cancer cell motility cycle which drives the formation of cell protrusions and defines the direction of migration. Cofilin, a significant actin-regulating molecule, regulates the migration of cancer cells by the formation of lamellipodia and filopodia, however, little is known about the upstream regulation of cofilin. In this study, the effect of atypical Protein Kinase C (atypical PKC) on Cofilin activity in CRC was studied. This study demonstrates that the atypical PKC inhibition impedes the metastasis of CRC cells by increasing phospho-Cofilin (S3) and changing actin organization.http://dx.doi.org/10.1080/19336918.2018.1546513crcmetastasisactin dynamicspkc-ιpkc-ζcofilin
collection DOAJ
language English
format Article
sources DOAJ
author S M Anisul Islam
Rekha Patel
Raja Reddy Bommareddy
Khandker Mohammad Khalid
Mildred Acevedo-Duncan
spellingShingle S M Anisul Islam
Rekha Patel
Raja Reddy Bommareddy
Khandker Mohammad Khalid
Mildred Acevedo-Duncan
The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells
Cell Adhesion & Migration
crc
metastasis
actin dynamics
pkc-ι
pkc-ζ
cofilin
author_facet S M Anisul Islam
Rekha Patel
Raja Reddy Bommareddy
Khandker Mohammad Khalid
Mildred Acevedo-Duncan
author_sort S M Anisul Islam
title The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells
title_short The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells
title_full The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells
title_fullStr The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells
title_full_unstemmed The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells
title_sort modulation of actin dynamics via atypical protein kinase-c activated cofilin regulates metastasis of colorectal cancer cells
publisher Taylor & Francis Group
series Cell Adhesion & Migration
issn 1933-6918
1933-6926
publishDate 2019-01-01
description Colorectal cancer (CRC) is the third most common cancer in the United States. The exact mechanism of CRC cells metastasis is poorly understood. Actin polymerization is thought to be an initial step in the cancer cell motility cycle which drives the formation of cell protrusions and defines the direction of migration. Cofilin, a significant actin-regulating molecule, regulates the migration of cancer cells by the formation of lamellipodia and filopodia, however, little is known about the upstream regulation of cofilin. In this study, the effect of atypical Protein Kinase C (atypical PKC) on Cofilin activity in CRC was studied. This study demonstrates that the atypical PKC inhibition impedes the metastasis of CRC cells by increasing phospho-Cofilin (S3) and changing actin organization.
topic crc
metastasis
actin dynamics
pkc-ι
pkc-ζ
cofilin
url http://dx.doi.org/10.1080/19336918.2018.1546513
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