Using genetic prediction from known complex disease Loci to guide the design of next-generation sequencing experiments.
A central focus of complex disease genetics after genome-wide association studies (GWAS) is to identify low frequency and rare risk variants, which may account for an important fraction of disease heritability unexplained by GWAS. A profusion of studies using next-generation sequencing are seeking s...
Main Authors: | Luke Jostins, Adam P Levine, Jeffrey C Barrett |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3799779?pdf=render |
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