Using an achiasmic human visual system to quantify the relationship between the fMRI BOLD signal and neural response
Achiasma in humans causes gross mis-wiring of the retinal-fugal projection, resulting in overlapped cortical representations of left and right visual hemifields. We show that in areas V1-V3 this overlap is due to two co-located but non-interacting populations of neurons, each with a receptive field...
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doaj-331995c6672a45e39d8622b14246f2d62021-05-05T00:08:13ZengeLife Sciences Publications LtdeLife2050-084X2015-11-01410.7554/eLife.09600Using an achiasmic human visual system to quantify the relationship between the fMRI BOLD signal and neural responsePinglei Bao0Christopher J Purington1Bosco S Tjan2https://orcid.org/0000-0003-1290-5811Neuroscience Graduate Program, University of Southern California, Los Angeles, United StatesSchool of Optometry, University of California, Berkeley, Berkeley, CA, United States; Vision Science Graduate Program, University of California, Berkeley, Berkeley, United States; Department of Psychology, University of Southern California, Los Angeles, CA, United StatesNeuroscience Graduate Program, University of Southern California, Los Angeles, United States; Department of Psychology, University of Southern California, Los Angeles, CA, United StatesAchiasma in humans causes gross mis-wiring of the retinal-fugal projection, resulting in overlapped cortical representations of left and right visual hemifields. We show that in areas V1-V3 this overlap is due to two co-located but non-interacting populations of neurons, each with a receptive field serving only one hemifield. Importantly, the two populations share the same local vascular control, resulting in a unique organization useful for quantifying the relationship between neural and fMRI BOLD responses without direct measurement of neural activity. Specifically, we can non-invasively double local neural responses by stimulating both neuronal populations with identical stimuli presented symmetrically across the vertical meridian to both visual hemifields, versus one population by stimulating in one hemifield. Measurements from a series of such doubling experiments show that the amplitude of BOLD response is proportional to approximately 0.5 power of the underlying neural response. Reanalyzing published data shows that this inferred relationship is general.https://elifesciences.org/articles/09600ashiasmaanomalous retinotopyluminance contrast responsefMRI BOLD signalneurovascular couplingBOLD nonlinearity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pinglei Bao Christopher J Purington Bosco S Tjan |
spellingShingle |
Pinglei Bao Christopher J Purington Bosco S Tjan Using an achiasmic human visual system to quantify the relationship between the fMRI BOLD signal and neural response eLife ashiasma anomalous retinotopy luminance contrast response fMRI BOLD signal neurovascular coupling BOLD nonlinearity |
author_facet |
Pinglei Bao Christopher J Purington Bosco S Tjan |
author_sort |
Pinglei Bao |
title |
Using an achiasmic human visual system to quantify the relationship between the fMRI BOLD signal and neural response |
title_short |
Using an achiasmic human visual system to quantify the relationship between the fMRI BOLD signal and neural response |
title_full |
Using an achiasmic human visual system to quantify the relationship between the fMRI BOLD signal and neural response |
title_fullStr |
Using an achiasmic human visual system to quantify the relationship between the fMRI BOLD signal and neural response |
title_full_unstemmed |
Using an achiasmic human visual system to quantify the relationship between the fMRI BOLD signal and neural response |
title_sort |
using an achiasmic human visual system to quantify the relationship between the fmri bold signal and neural response |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2015-11-01 |
description |
Achiasma in humans causes gross mis-wiring of the retinal-fugal projection, resulting in overlapped cortical representations of left and right visual hemifields. We show that in areas V1-V3 this overlap is due to two co-located but non-interacting populations of neurons, each with a receptive field serving only one hemifield. Importantly, the two populations share the same local vascular control, resulting in a unique organization useful for quantifying the relationship between neural and fMRI BOLD responses without direct measurement of neural activity. Specifically, we can non-invasively double local neural responses by stimulating both neuronal populations with identical stimuli presented symmetrically across the vertical meridian to both visual hemifields, versus one population by stimulating in one hemifield. Measurements from a series of such doubling experiments show that the amplitude of BOLD response is proportional to approximately 0.5 power of the underlying neural response. Reanalyzing published data shows that this inferred relationship is general. |
topic |
ashiasma anomalous retinotopy luminance contrast response fMRI BOLD signal neurovascular coupling BOLD nonlinearity |
url |
https://elifesciences.org/articles/09600 |
work_keys_str_mv |
AT pingleibao usinganachiasmichumanvisualsystemtoquantifytherelationshipbetweenthefmriboldsignalandneuralresponse AT christopherjpurington usinganachiasmichumanvisualsystemtoquantifytherelationshipbetweenthefmriboldsignalandneuralresponse AT boscostjan usinganachiasmichumanvisualsystemtoquantifytherelationshipbetweenthefmriboldsignalandneuralresponse |
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