Smenamides A and B, Chlorinated Peptide/Polyketide Hybrids Containing a Dolapyrrolidinone Unit from the Caribbean Sponge Smenospongia aurea. Evaluation of Their Role as Leads in Antitumor Drug Research

Smenamides A and B, Chlorinated Peptide/Polyketide Hybrids Containing a Dolapyrrolidinone Unit from the Caribbean Sponge Smenospongia aurea. Evaluation of Their Role as Leads in Antitumor Drug Research

An in-depth study of the secondary metabolites contained in the Caribbean sponge Smenospongia aurea led to the isolation of smenamide A (1) and B (2), hybrid peptide/polyketide compounds containing a dolapyrrolidinone unit. Their structures were elucidated using high-resolution ESI-MS/MS and homo- a...

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Bibliographic Details
Main Authors: Valeria Costantino, Alfonso Mangoni, Elena Irollo, Giuseppe Pirozzi, Gerardo Della Sala, Roberta Teta
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Marine Drugs
Subjects:
Smenospongia aurea
marine natural products
peptide/polyketides hybrids
structure elucidation
antitumor activity
Online Access:http://www.mdpi.com/1660-3397/11/11/4451

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http://www.mdpi.com/1660-3397/11/11/4451

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