Polyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation.

Polyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation.

<h4>Background</h4>Polyglutamine expansion disorders are caused by an expansion of the polyglutamine (polyQ) tract in the disease related protein, leading to severe neurodegeneration. All polyQ disorders are hallmarked by the presence of intracellular aggregates containing the expanded p...

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Bibliographic Details
Main Authors: Hilde A Krol, Przemek M Krawczyk, Klazien S Bosch, Jacob A Aten, Elly M Hol, Eric A Reits
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18231590/pdf/?tool=EBI

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