Interaction of Osteoarthritis and BMI on <i>Leptin</i> Promoter Methylation in Taiwanese Adults
<i>Leptin</i> (<i>LEP</i>) regulates glucose metabolism and energy storage in the body. Osteoarthritis (OA) is associated with the upregulation of serum <i>LEP</i>. <i>LEP</i> promoter methylation is associated with obesity. So far, few studies have ex...
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doaj-3320d53af6464b6781fdc85b1cf4bf302020-11-25T02:21:16ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-12-0121112310.3390/ijms21010123ijms21010123Interaction of Osteoarthritis and BMI on <i>Leptin</i> Promoter Methylation in Taiwanese AdultsTzi-Peng Yang0Hsiao-Mei Chen1Chao-Chin Hu2Li-Yuan Chen3Fen-Fen Shih4Disline Manli Tantoh5Kuan-Jung Lee6Yi-Chia Liaw7Rong-Tzong Tsai8Yung-Po Liaw9Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Nursing, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Medical Applied Chemistry, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Physical Therapy, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Nursing, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Medical Imaging, Chung Shan Medical University Hospital, Taichung 40201, TaiwanDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung 40201, TaiwanDivision of Neurology, Neurology Institute, Taipei Veterans General Hospital, Taipei 112, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Medical Imaging, Chung Shan Medical University Hospital, Taichung 40201, Taiwan<i>Leptin</i> (<i>LEP</i>) regulates glucose metabolism and energy storage in the body. Osteoarthritis (OA) is associated with the upregulation of serum <i>LEP</i>. <i>LEP</i> promoter methylation is associated with obesity. So far, few studies have explored the association of BMI and OA with <i>LEP</i> methylation. We assessed the interaction between body mass index (BMI) and OA on <i>LEP</i> promoter methylation. Data of 1114 participants comprising 583 men and 558 women, aged 30−70 years were retrieved from the Taiwan Biobank Database (2008−2015). Osteoarthritis was self-reported and cases were those who reported having ever been clinically diagnosed with osteoarthritis. BMI was categorized into underweight, normal weight, overweight, and obesity. The mean <i>LEP</i> promoter methylation level in individuals with osteoarthritis was 0.5509 ± 0.00437 and 0.5375 ± 0.00101 in those without osteoarthritis. The interaction between osteoarthritis and BMI on <i>LEP</i> promoter methylation was significant (<i>p</i>-value = 0.0180). With normal BMI as the reference, the mean <i>LEP</i> promoter methylation level was significantly higher in obese osteoarthritic individuals (<i>β</i> = 0.03696, <i>p</i>-value = 0.0187). However, there was no significant association between BMI and <i>LEP</i> promoter methylation in individuals without osteoarthritis, regardless of BMI. In conclusion, only obesity was significantly associated with <i>LEP</i> promoter methylation (higher levels) specifically in osteoarthritic patients.https://www.mdpi.com/1422-0067/21/1/123bmi<i>lep</i>obesitymethylationosteoarthritis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tzi-Peng Yang Hsiao-Mei Chen Chao-Chin Hu Li-Yuan Chen Fen-Fen Shih Disline Manli Tantoh Kuan-Jung Lee Yi-Chia Liaw Rong-Tzong Tsai Yung-Po Liaw |
spellingShingle |
Tzi-Peng Yang Hsiao-Mei Chen Chao-Chin Hu Li-Yuan Chen Fen-Fen Shih Disline Manli Tantoh Kuan-Jung Lee Yi-Chia Liaw Rong-Tzong Tsai Yung-Po Liaw Interaction of Osteoarthritis and BMI on <i>Leptin</i> Promoter Methylation in Taiwanese Adults International Journal of Molecular Sciences bmi <i>lep</i> obesity methylation osteoarthritis |
author_facet |
Tzi-Peng Yang Hsiao-Mei Chen Chao-Chin Hu Li-Yuan Chen Fen-Fen Shih Disline Manli Tantoh Kuan-Jung Lee Yi-Chia Liaw Rong-Tzong Tsai Yung-Po Liaw |
author_sort |
Tzi-Peng Yang |
title |
Interaction of Osteoarthritis and BMI on <i>Leptin</i> Promoter Methylation in Taiwanese Adults |
title_short |
Interaction of Osteoarthritis and BMI on <i>Leptin</i> Promoter Methylation in Taiwanese Adults |
title_full |
Interaction of Osteoarthritis and BMI on <i>Leptin</i> Promoter Methylation in Taiwanese Adults |
title_fullStr |
Interaction of Osteoarthritis and BMI on <i>Leptin</i> Promoter Methylation in Taiwanese Adults |
title_full_unstemmed |
Interaction of Osteoarthritis and BMI on <i>Leptin</i> Promoter Methylation in Taiwanese Adults |
title_sort |
interaction of osteoarthritis and bmi on <i>leptin</i> promoter methylation in taiwanese adults |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-12-01 |
description |
<i>Leptin</i> (<i>LEP</i>) regulates glucose metabolism and energy storage in the body. Osteoarthritis (OA) is associated with the upregulation of serum <i>LEP</i>. <i>LEP</i> promoter methylation is associated with obesity. So far, few studies have explored the association of BMI and OA with <i>LEP</i> methylation. We assessed the interaction between body mass index (BMI) and OA on <i>LEP</i> promoter methylation. Data of 1114 participants comprising 583 men and 558 women, aged 30−70 years were retrieved from the Taiwan Biobank Database (2008−2015). Osteoarthritis was self-reported and cases were those who reported having ever been clinically diagnosed with osteoarthritis. BMI was categorized into underweight, normal weight, overweight, and obesity. The mean <i>LEP</i> promoter methylation level in individuals with osteoarthritis was 0.5509 ± 0.00437 and 0.5375 ± 0.00101 in those without osteoarthritis. The interaction between osteoarthritis and BMI on <i>LEP</i> promoter methylation was significant (<i>p</i>-value = 0.0180). With normal BMI as the reference, the mean <i>LEP</i> promoter methylation level was significantly higher in obese osteoarthritic individuals (<i>β</i> = 0.03696, <i>p</i>-value = 0.0187). However, there was no significant association between BMI and <i>LEP</i> promoter methylation in individuals without osteoarthritis, regardless of BMI. In conclusion, only obesity was significantly associated with <i>LEP</i> promoter methylation (higher levels) specifically in osteoarthritic patients. |
topic |
bmi <i>lep</i> obesity methylation osteoarthritis |
url |
https://www.mdpi.com/1422-0067/21/1/123 |
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