Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2

Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2

HAP2 is essential for gamete fusion during fertilization and is conserved among eukaryotes. Here the authors show that species-specific adhesion between Chlamydomonas plus and minus gametes initiates HAP2 to undergo a fusogenic conformational change into homotrimers via a molecular mechanism akin to...

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Main Authors: Jun Zhang, Jennifer F. Pinello, Ignacio Fernández, Eduard Baquero, Juliette Fedry, Félix A. Rey, William J. Snell
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24613-8
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spelling doaj-332183e39cc842d0b8b505ff83c67ce62021-07-25T11:38:25ZengNature Publishing GroupNature Communications2041-17232021-07-0112111210.1038/s41467-021-24613-8Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2Jun Zhang0Jennifer F. Pinello1Ignacio Fernández2Eduard Baquero3Juliette Fedry4Félix A. Rey5William J. Snell6Department of Cell Biology and Molecular Genetics, University of MarylandDepartment of Cell Biology and Molecular Genetics, University of MarylandUnité de Virologie Structurale, Virology Department and CNRS UMR 3569, Institut PasteurUnité de Virologie Structurale, Virology Department and CNRS UMR 3569, Institut PasteurUnité de Virologie Structurale, Virology Department and CNRS UMR 3569, Institut PasteurUnité de Virologie Structurale, Virology Department and CNRS UMR 3569, Institut PasteurDepartment of Cell Biology and Molecular Genetics, University of MarylandHAP2 is essential for gamete fusion during fertilization and is conserved among eukaryotes. Here the authors show that species-specific adhesion between Chlamydomonas plus and minus gametes initiates HAP2 to undergo a fusogenic conformational change into homotrimers via a molecular mechanism akin to that of enveloped viruses.https://doi.org/10.1038/s41467-021-24613-8
collection DOAJ
language English
format Article
sources DOAJ
author Jun Zhang
Jennifer F. Pinello
Ignacio Fernández
Eduard Baquero
Juliette Fedry
Félix A. Rey
William J. Snell
spellingShingle Jun Zhang
Jennifer F. Pinello
Ignacio Fernández
Eduard Baquero
Juliette Fedry
Félix A. Rey
William J. Snell
Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
Nature Communications
author_facet Jun Zhang
Jennifer F. Pinello
Ignacio Fernández
Eduard Baquero
Juliette Fedry
Félix A. Rey
William J. Snell
author_sort Jun Zhang
title Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
title_short Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
title_full Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
title_fullStr Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
title_full_unstemmed Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
title_sort species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen hap2
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-07-01
description HAP2 is essential for gamete fusion during fertilization and is conserved among eukaryotes. Here the authors show that species-specific adhesion between Chlamydomonas plus and minus gametes initiates HAP2 to undergo a fusogenic conformational change into homotrimers via a molecular mechanism akin to that of enveloped viruses.
url https://doi.org/10.1038/s41467-021-24613-8
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AT jenniferfpinello speciesspecificgameterecognitioninitiatesfusiondrivingtrimerformationbyconservedfusogenhap2
AT ignaciofernandez speciesspecificgameterecognitioninitiatesfusiondrivingtrimerformationbyconservedfusogenhap2
AT eduardbaquero speciesspecificgameterecognitioninitiatesfusiondrivingtrimerformationbyconservedfusogenhap2
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