Evaluation of ADCratio on liver MRI diffusion to discriminate benign versus malignant solid liver lesions
Purpose: The aim of this project is to investigate the usefulness of the absolute liver lesion ADC value and ratio of Apparent diffusion coefficient (ADC) values of a liver lesion and liver parenchyma to discriminate between a benign and malignant lesion.Methods: Liver MRI scans performed between Ja...
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doaj-33239488f5a0419693058f1699482fed2020-11-24T21:49:55ZengElsevierEuropean Journal of Radiology Open2352-04772018-01-015209214Evaluation of ADCratio on liver MRI diffusion to discriminate benign versus malignant solid liver lesionsTarun Pankaj Jain0Wen Ter Kan1Sean Edward2Helen Fernon3Renuvathy Kansan Naider4Universal Medical Imaging, 1/110 Giles street, Kingston, ACT 2604, Canada; Medical Imaging Department, The Canberra Hospital, Garran, ACT 2606, AustraliaMedical Imaging Department, The Canberra Hospital, Garran, ACT 2606, Australia; Corresponding author.Medical Imaging Department, The Canberra Hospital, Garran, ACT 2606, AustraliaUniversal Medical Imaging, 1/110 Giles street, Kingston, ACT 2604, CanadaThe Canberra Hospital, Garran, ACT 2606, AustraliaPurpose: The aim of this project is to investigate the usefulness of the absolute liver lesion ADC value and ratio of Apparent diffusion coefficient (ADC) values of a liver lesion and liver parenchyma to discriminate between a benign and malignant lesion.Methods: Liver MRI scans performed between January 2009 and June 2015 were retrospectively analysed. Scans were performed on either a 1.5 T or 3 T MRI unit. The type of liver lesion (benign or malignant) was determined by its radiological appearance, histology result and clinical management. Lesions with undetermined diagnosis or MRI studies degraded by artifacts were excluded. Liver cysts were also excluded from the analysis. ADC value of a lesion and liver parenchyma was measured and ADCratio was calculated. The values were analysed using independent samples t-testResults:Data set contained 39 benign lesions and 36 malignant lesions. Mean ADC value for benign lesions was 1678, and the mean value for malignant lesions was 1097 with a statistically significant difference of p < 0.001. All lesions with ADC value below 955 were malignant, while all lesions with ADC value above 1880 were benign. ADC value of 1260 was identified as the best available cut-off value for differentiating benign and malignant lesions, achieving sensitivity of 92%, specificity of 80% and an overall accuracy of 89%. The mean lesion to liver ADCratio for benign lesions was 1.3467 and for malignant lesions was 0.9038 with a statistically significant difference of p < 0.001. All lesions with ADCratio measuring <0.9 were malignant while lesions with ADCratio>1.5 were benign. ADCratio of 1.1 was identified statistically as the best available cut-off value for differentiating benign from malignant lesions, with sensitivity of 82%, specificity of 86% and an overall accuracy of 92%.Conclusion:Our dataset indicates that lesion to background liver ADCratio is superior in discriminating between benign and malignant focal lesions compared to absolute ADC values of the hepatic lesions. Keywords: Magnetic resonance imaging (MRI), Liver lesion, Benign, Malignant, Apparent diffusion coefficient (ADC), Apparent diffusion coefficient ratio. (ADCratio)http://www.sciencedirect.com/science/article/pii/S2352047718300315 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tarun Pankaj Jain Wen Ter Kan Sean Edward Helen Fernon Renuvathy Kansan Naider |
spellingShingle |
Tarun Pankaj Jain Wen Ter Kan Sean Edward Helen Fernon Renuvathy Kansan Naider Evaluation of ADCratio on liver MRI diffusion to discriminate benign versus malignant solid liver lesions European Journal of Radiology Open |
author_facet |
Tarun Pankaj Jain Wen Ter Kan Sean Edward Helen Fernon Renuvathy Kansan Naider |
author_sort |
Tarun Pankaj Jain |
title |
Evaluation of ADCratio on liver MRI diffusion to discriminate benign versus malignant solid liver lesions |
title_short |
Evaluation of ADCratio on liver MRI diffusion to discriminate benign versus malignant solid liver lesions |
title_full |
Evaluation of ADCratio on liver MRI diffusion to discriminate benign versus malignant solid liver lesions |
title_fullStr |
Evaluation of ADCratio on liver MRI diffusion to discriminate benign versus malignant solid liver lesions |
title_full_unstemmed |
Evaluation of ADCratio on liver MRI diffusion to discriminate benign versus malignant solid liver lesions |
title_sort |
evaluation of adcratio on liver mri diffusion to discriminate benign versus malignant solid liver lesions |
publisher |
Elsevier |
series |
European Journal of Radiology Open |
issn |
2352-0477 |
publishDate |
2018-01-01 |
description |
Purpose: The aim of this project is to investigate the usefulness of the absolute liver lesion ADC value and ratio of Apparent diffusion coefficient (ADC) values of a liver lesion and liver parenchyma to discriminate between a benign and malignant lesion.Methods: Liver MRI scans performed between January 2009 and June 2015 were retrospectively analysed. Scans were performed on either a 1.5 T or 3 T MRI unit. The type of liver lesion (benign or malignant) was determined by its radiological appearance, histology result and clinical management. Lesions with undetermined diagnosis or MRI studies degraded by artifacts were excluded. Liver cysts were also excluded from the analysis. ADC value of a lesion and liver parenchyma was measured and ADCratio was calculated. The values were analysed using independent samples t-testResults:Data set contained 39 benign lesions and 36 malignant lesions. Mean ADC value for benign lesions was 1678, and the mean value for malignant lesions was 1097 with a statistically significant difference of p < 0.001. All lesions with ADC value below 955 were malignant, while all lesions with ADC value above 1880 were benign. ADC value of 1260 was identified as the best available cut-off value for differentiating benign and malignant lesions, achieving sensitivity of 92%, specificity of 80% and an overall accuracy of 89%. The mean lesion to liver ADCratio for benign lesions was 1.3467 and for malignant lesions was 0.9038 with a statistically significant difference of p < 0.001. All lesions with ADCratio measuring <0.9 were malignant while lesions with ADCratio>1.5 were benign. ADCratio of 1.1 was identified statistically as the best available cut-off value for differentiating benign from malignant lesions, with sensitivity of 82%, specificity of 86% and an overall accuracy of 92%.Conclusion:Our dataset indicates that lesion to background liver ADCratio is superior in discriminating between benign and malignant focal lesions compared to absolute ADC values of the hepatic lesions. Keywords: Magnetic resonance imaging (MRI), Liver lesion, Benign, Malignant, Apparent diffusion coefficient (ADC), Apparent diffusion coefficient ratio. (ADCratio) |
url |
http://www.sciencedirect.com/science/article/pii/S2352047718300315 |
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