A Near-Infrared Light-Responsive Hybrid Hydrogel Based on UCST Triblock Copolymer and Gold Nanorods
We report a near-infrared (NIR) light-responsive hydrogel that is capable of undergoing the gel to sol transition upon 785 nm light exposure based on a photothermal effect. The new hydrogel design relies on loading gold nanorods (AuNRs) in an ABA-type triblock copolymer, namely P(AAm–co–AN)–b–PDMA–b...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2017-06-01
|
Series: | Polymers |
Subjects: | |
Online Access: | http://www.mdpi.com/2073-4360/9/6/238 |
id |
doaj-332a02deac4f4598b896453ebea35783 |
---|---|
record_format |
Article |
spelling |
doaj-332a02deac4f4598b896453ebea357832020-11-24T22:21:41ZengMDPI AGPolymers2073-43602017-06-019623810.3390/polym9060238polym9060238A Near-Infrared Light-Responsive Hybrid Hydrogel Based on UCST Triblock Copolymer and Gold NanorodsHu Zhang0Shengwei Guo1Shangyi Fu2Yue Zhao3Département de Chimie, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, CanadaDépartement de Chimie, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, CanadaDépartement de Chimie, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, CanadaDépartement de Chimie, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, CanadaWe report a near-infrared (NIR) light-responsive hydrogel that is capable of undergoing the gel to sol transition upon 785 nm light exposure based on a photothermal effect. The new hydrogel design relies on loading gold nanorods (AuNRs) in an ABA-type triblock copolymer, namely P(AAm–co–AN)–b–PDMA–b–P(AAm–co–AN), where P(AAm–co–AN) stands for a random copolymer of acrylamide and acrylonitrile that exhibits an upper critical solution temperature (UCST) in aqueous solution and PDMA is water-soluble polydimethylacrylamide. At solution temperature below UCST, the insoluble P(AAm–co–AN) blocks lead to formation of hydrogel of flower-like micelles. When the hydrogel is exposed to 785 nm NIR light, the absorption due to the longitudinal surface plasmon resonance of loaded AuNRs generates heat that raises the hydrogel temperature above UCST and, consequently, the gel-to-sol transition. The NIR light-triggered release of a protein loaded in the hydrogel was found to display a switchable fashion.http://www.mdpi.com/2073-4360/9/6/238near-infrared light-sensitive polymerblock copolymer hydrogelthermosensitive polymerupper critical solution temperaturephotothermal effect |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hu Zhang Shengwei Guo Shangyi Fu Yue Zhao |
spellingShingle |
Hu Zhang Shengwei Guo Shangyi Fu Yue Zhao A Near-Infrared Light-Responsive Hybrid Hydrogel Based on UCST Triblock Copolymer and Gold Nanorods Polymers near-infrared light-sensitive polymer block copolymer hydrogel thermosensitive polymer upper critical solution temperature photothermal effect |
author_facet |
Hu Zhang Shengwei Guo Shangyi Fu Yue Zhao |
author_sort |
Hu Zhang |
title |
A Near-Infrared Light-Responsive Hybrid Hydrogel Based on UCST Triblock Copolymer and Gold Nanorods |
title_short |
A Near-Infrared Light-Responsive Hybrid Hydrogel Based on UCST Triblock Copolymer and Gold Nanorods |
title_full |
A Near-Infrared Light-Responsive Hybrid Hydrogel Based on UCST Triblock Copolymer and Gold Nanorods |
title_fullStr |
A Near-Infrared Light-Responsive Hybrid Hydrogel Based on UCST Triblock Copolymer and Gold Nanorods |
title_full_unstemmed |
A Near-Infrared Light-Responsive Hybrid Hydrogel Based on UCST Triblock Copolymer and Gold Nanorods |
title_sort |
near-infrared light-responsive hybrid hydrogel based on ucst triblock copolymer and gold nanorods |
publisher |
MDPI AG |
series |
Polymers |
issn |
2073-4360 |
publishDate |
2017-06-01 |
description |
We report a near-infrared (NIR) light-responsive hydrogel that is capable of undergoing the gel to sol transition upon 785 nm light exposure based on a photothermal effect. The new hydrogel design relies on loading gold nanorods (AuNRs) in an ABA-type triblock copolymer, namely P(AAm–co–AN)–b–PDMA–b–P(AAm–co–AN), where P(AAm–co–AN) stands for a random copolymer of acrylamide and acrylonitrile that exhibits an upper critical solution temperature (UCST) in aqueous solution and PDMA is water-soluble polydimethylacrylamide. At solution temperature below UCST, the insoluble P(AAm–co–AN) blocks lead to formation of hydrogel of flower-like micelles. When the hydrogel is exposed to 785 nm NIR light, the absorption due to the longitudinal surface plasmon resonance of loaded AuNRs generates heat that raises the hydrogel temperature above UCST and, consequently, the gel-to-sol transition. The NIR light-triggered release of a protein loaded in the hydrogel was found to display a switchable fashion. |
topic |
near-infrared light-sensitive polymer block copolymer hydrogel thermosensitive polymer upper critical solution temperature photothermal effect |
url |
http://www.mdpi.com/2073-4360/9/6/238 |
work_keys_str_mv |
AT huzhang anearinfraredlightresponsivehybridhydrogelbasedonucsttriblockcopolymerandgoldnanorods AT shengweiguo anearinfraredlightresponsivehybridhydrogelbasedonucsttriblockcopolymerandgoldnanorods AT shangyifu anearinfraredlightresponsivehybridhydrogelbasedonucsttriblockcopolymerandgoldnanorods AT yuezhao anearinfraredlightresponsivehybridhydrogelbasedonucsttriblockcopolymerandgoldnanorods AT huzhang nearinfraredlightresponsivehybridhydrogelbasedonucsttriblockcopolymerandgoldnanorods AT shengweiguo nearinfraredlightresponsivehybridhydrogelbasedonucsttriblockcopolymerandgoldnanorods AT shangyifu nearinfraredlightresponsivehybridhydrogelbasedonucsttriblockcopolymerandgoldnanorods AT yuezhao nearinfraredlightresponsivehybridhydrogelbasedonucsttriblockcopolymerandgoldnanorods |
_version_ |
1725770018732376064 |