From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the...

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Bibliographic Details
Main Authors: Antoine Taly, Adak Nasiripourdori, Valérie Taly, Thomas Grutter
Format: Article
Language:English
Published: MDPI AG 2011-03-01
Series:Toxins
Subjects:
nAChR
P2X
GABA
Glycine
Serotonin
NMDA
AMPA
Kainate
Online Access:http://www.mdpi.com/2072-6651/3/3/260/
Description
Summary:Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.
ISSN:2072-6651

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